Oral administration chewable tablets

Absorption/Distribution - Lamotrigine is rapidly and completely absorbed after oral administration. Absolute bioavailability is 98%. Peak plasma concentrations occur anywhere from 1.4 to 4.8 hours following drug administration. Lamotrigine chewable/dispersible tablets were found to be equivalent, whether they were administered as dispersed in water, chewed and swallowed, or swallowed as whole, to lamotrigine compressed tablets in terms of rate and extent of absorption. 

The oral bioavailability of didanosine is about 35 15%. Food may decrease its absorption by 50% or more. As a consequence, it should be administered a minimum of 30 min before or 2 h after eating. Peak plasma concentrations are reached within 1 or 2 h of administration after a chewable tablet and delayed release capsule,... 

Many oral solutions are intended for pediatric administration, of which oral solution formulations are a subset of a larger choice of formulation type such as suspension, syrup, powder or microcapsules for constitution to a suspension, powder for reconstitution to a solution or suspension, solid particles (powder, coated particles, extended release, enteric-coated granules, beads) in packets or capsules to be sprinkled on food, oral powders, and chewable tablets. The broader topic of pediatric formulation development is beyond the scope of this chapter, but this chapter will cover selected oral solutions for pediatric administration. 

Peak concentrations of didanosine are seen approximately 1 hour after oral administration of the chewable tablets or powder formulations and 2 hours after delayed-release capsules. The plasma elimination half-life of the parent drug is approximately 1.5 hours, but the estimated intracellular half-life of dideoxyadenosine 5 -triphosphate is substantially longer, 25 to 40 hours. As a result, didanosine can be administered once daily. Didanosine is excreted by both glomerular filtration and tubular secretion, and does not undergo metabolism to a significant degree. Drag doses therefore must be adjusted in patients with renal insnfficiency or renal failure. 

VI. Dosage and method of administration. In general, there are no clinically proven advantages of any one of the Hj blockers, although cimetidine is more likely to be associated with dmg-dmg interactions. The lowest-strength dosage forms are available OTC and several oral dosage fona options (chewable tablets, oral solutions) may enhance palatability. See Table III-3 for oral and parenteral doses. 

Caries inhibition resulting from daily administration of chewable tablets or mouth rinses may be due to incorporation of absorbable fluoride into the developing enamel teeth surfaces. The retention of fluoride following oral rinses [311, 315, 336] or tablet chewing [336] has been followed by analysing the fluoride of the oral expectorates. The anti-caries effect of ionic fluoride might then be evaluated in relation to fluoride retention [311]. Perkins found oral retentions of 41, 20 and 7 per cent of the fluoride dose, respectively, administered as... 

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