Optofluidic Manipulation of Biological

Optofluidic Manipulation of Biological Molecules, Fig. 1 Optical manipulation of suspended particles by direct optical tweezers... 

Optofluidic Manipulation of Biological Molecules, Fig. 4 (a) Cells within the microchannel can be localized and classified with bright-field (green) and/or fluorescence (blue) illumination through a high-NA objective. Once a cell is classified, it is moved by optical tweezers (red) to a streamline of laminar flow which leads to the outlet for sorted cells, (b, c) Photographs of microfluidic chamber inserted into its chip holder and connected to... 

Optofluidic Manipulation of Biological Molecules, Fig. 10 SEM images and transmission spectra of microring resonator, (a, b) SEM image of microring with radii of (a) 5 pm and (b) 10 pm. (c, d) Transmission spectra of rings with radii of (c) 5 and (d) 10 pm, respectively. The black squares are measured output powers. 

Optofluidic Manipulation of Biological Molecules, Fig. 11 Binding assay for GFP sensing, (a) Schematic diagram of the binding assay. Inset fluorescent microscopy image of a cluster with two particles bound by GFP. (b-e) Resonance wavelength shifts for samples (b) without GFP and with GFP, at concentrations of (c) 10 nM,... 

The on-chip optofluidic technology has emerged as a powerful and efficient tool for on-chip manipulation of particles, biological cells, and biomolecules. Different kinds of optofluidic manipulation chips based on different optical components have been developed to achieve ultrasensitive manipulation of biomolecules. In the point of near-field optofluidic manipulation, Bradley and Erickson developed planar SU-8-based waveguide to trap and transport the biopolymer in the evanescent field [2]. Olav et al. developed an optical waveguide loop to achieve the stable trapping of red blood cells and demonstrate the potentials which can... 

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