Opioids chemokine interactions

Opioid-Chemokine Interactions 16.2.1 Chemokine Ligands and Receptors... 

Considerable evidence for opioid-chemokine interactions comes from studies of pain and inflammation, where the inherent relationships between pain, inflammation, and the counteracting antinociceptive influences of opioids have considerable biomedical implications. The adaptive changes in immune and nervous system function with chronic inflammation and pain further reveal the inherent interrelatedness between opioids (Ossipov et al. 2003 Evans 2004 Roy et al. 2006 Christie 2008)... 

Interaction Between Opioid and Chemokine Receptors in Immune Cells Implications for HIV Infection... 

In this chapter, we review the interactions at the level of protein function, between opioid receptors and chemokine receptors, using both in vitro and in vivo model systems. As a part of this discussion, we also describe our current understanding of the biochemical pathway(s) that are involved in the heterologous desensitization process between these groups of receptors. 

Suzuki S, Chuang LE, Yau P, Doi RH, Chuang RY (2002b) Interactions of opioid and chemokine receptors oligomerization of mu, kappa, and delta with CCR5 on immune cells. Exp Cell Res 280 192-200... 

As one might expect, similar interactions between chemokine and opioid systems have been observed in the central nervous system as weU. In 2002, Szabo et al. 

Steele AD, Szabo I, Bednar F, Rogers TJ (2002) Interactions between opioid and chemokine receptors Heterologous desensitization. Cytok Growth Factor Rev 13 209-222. 

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