Opioids analgesics drugs

These differences in the behavioural properties of the opioid receptor sub-types are of considerable interest because the clinical use of currently marketed opioid analgesic drugs is limited by their undesirable side-effects, which include respiratory depression, constipation and an abuse or dependence liability. These side-effects have been associated with mu receptor ac-... [Pg.114]

Sufentanil is a synthetic opioid analgesic drug, as outlined in CHEC-II(1996), and is approximately 5-10 times more potent than fentanyl. Sufentanil is marketed for use by specialist centers under different trade names. Other thiophene derivatives, such as the benzimidazol-thiophenes 16 and 17, exhibit analgesic activity that can be compared with morphine sulfate and acetylsalicylic acid <2005PS1841>. [Pg.934]

Duthie DJ, Nimmo WS. Adverse effects of opioid analgesic drugs. Br J Anaesth 1987 59(l) 61-77. [Pg.2635]

These peptides are relevant to understanding the analgesic actions of opioid-analgesic drugs in terms of CNS function. What are the roles of these peptides in peripheral tissues The Skill Keeper Answer appears at the end of the chapter. [Pg.281]

Unpublished data quoted by Maurer PM, Barkowski RR. Drug interactions of clinical significance with opioid analgesics. Drug Sefety (1993) 8,30-48. [Pg.172]

Opioid analgesic drugs (OADs), particularly fentanyl and its analogs alfentanil, remifentanil, and sufentanil, are extensively used for anesthesia and analgesia. Administration of intravenous hypnotics and OADs as a high dose opioid, low dose hypnotic (usually a benzodiazepine such as midazolam) has found wide application in cardiac anesthesia and to produce procedural sedation for endoscopy, catheterizations, and a variety of other surgical procedures where sedation and... [Pg.295]

From Baldo BA, Pham NH. Histamine-releasing and aUergenic properties of opioid analgesic drugs Resolving the two. Anaesth Intensive Care. 2012 40 216. Reproduced with permission from Australian Society of Anaesthetists Has a 1-hydroxy-1,2,2-trimethylpropyl substituent at C-7... [Pg.298]

IgE antibodies detected in two different sera from patients with suspected allergy to opioid analgesic drugs HgE antibodies detected by binding to a morphine-solid phase complex... [Pg.312]

Table 8.7 Summary of some case studies of anaphylactoid/anaphylactic reactions to opioid analgesic drugs and diagnostic conclusions... [Pg.314]

Some Important Clinical Implications Related to the Use of Opioid Analgesic Drugs... [Pg.316]

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