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Opioid receptor signaling

There are three classical opioid receptor types, p, 8, and K 914 Chronic opiate treatment results in complex adaptations in opioid receptor signaling 915... [Pg.911]

Chronic opiate treatment results in complex adaptations in opioid receptor signaling. Much has been learned from studies on mechanisms of tolerance to the analgesic effects of opiates. This is a major clinical problem, as it means that ever-escalating doses are required for the treatment of chronic pain. The classic view was that tolerance reflects a decrease in functional opioid receptors via desensitization and internalization. Desensitization occurs when receptors are uncoupled from G proteins as a result of phosphorylation by G-protein-coupled receptor... [Pg.915]

Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M. Functional dissociation of mu opioid receptor signaling and endocytosis implications for the biology of opiate tolerance and addiction. Neuron 1999 23 737-746. [Pg.233]

Law PY, Wong YH, Loh HH. Molecular mechanisms and regulation of opioid receptor signaling. Annu Rev Pharmacol Toxicol 2000 40 389-430. [Pg.28]

Jordan B, Devi LA. Molecular mechanisms of opioid receptor signal transduction. Br J Anaesth 1998 81(1) 12-19. [Pg.2635]

Opioid Receptor Signaling and Consequent Intracellular Events... [Pg.351]

Connor M, Christie MD. Opioid receptor signaling mechanisms. Clin Exp Pharmacol Physiol 1999 26 493-499. [Pg.1014]

Nagi K, Pineyro G. Regulation of opioid receptor signaling implications for the development of analgesic tolerance. Mol Brain 2011 4 25. [Pg.410]

Potenza MN, Gold SJ, Roby-Shcmkowitz A, et al Effects of regulators of G protein-signaling proteins on the functional response of the mu-opioid receptor in a mel-anophore-based assay. J Pharmacol Exp Ther 291 482 91, 1999 Quaglio G, Talamini G, Lechi A, et al Study of 2708 heroin-related deaths in northeastern Italy 1985—98 to establish the main causes of death. Addiction 96 1127— 1137, 2001... [Pg.106]

It is well established that NF-kB signaling plays a critical role in inflammation and immunity. Understanding the mechanism of NF-kB involvement in opioid receptor activation and chemokine expression may provide a vital key to understanding this complex signaling network. However, the elucidation of molecular mechanisms following activation of the opioid receptor family could aid in the development of future therapeutics for immune system-related and inflammatory diseases, drug addiction and HIV infection. [Pg.323]

Kraus J, Bomer C, Giannini E, HoUt V (2003) The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. Mol Pharmacol 64 876-884 Law PY, Loh HH, Wei LN (2004) Insights into the receptor transcription and signaling implications in opioid tolerance and dependence. [Review] [123 refs]. Neuropharmacology 47(Suppl 1) 300-311... [Pg.334]

Bohn LM, Belcheva MM, Coscia CJ (2000) p-opioid agonist inhibition of kappa-opioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. J Neurochem 74 574-581... [Pg.367]

Carpentier PA, Duncan DS, Miller SD (2008) GUal toU-hke receptor signaling in central nervous system infection and autoimmunity. Brain Behav Immun 22 140-147 Carr DJ, Serou M (1995) Exogenous and endogenous opioids as biological response modifiers. Immunopharmacology 31 59-71... [Pg.367]

Rogers TJ, Peterson PK (2003) Opioid G protein-coupled receptors signals at the crossroads of inflammation. Trends Immunol 24 116-121... [Pg.375]

Sharp BM (2003) Opioid receptor expression and intracellular signaling by cells involved in host defense and immunity. Adv Exp Med Biol 521 98-105 Sharp BM (2006) Multiple opioid receptors on immune cells modulate intracellular signaling. Brain Behav Immun 20 9-14... [Pg.375]

Zheng H, Chu J, Qiu Y, Loh HH, Law PY (2008) Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc Natl Acad Sci USA 105 9421-9426 Zhu Y, Hsu MS, Pintar JE (1998) Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse. J Neurosci 18 2538-2549... [Pg.378]

CXCR4 and Opioid Receptors in the CNS Distribution, Signaling, and Involvement in Neuropathology... [Pg.379]

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See also in sourсe #XX -- [ Pg.351 ]



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