Oncology drug discovery

Figure 11-1 Recommended toxicology/pathology activities to support oncology drug discovery by stage.

Jackman, A., and Judson, I. 1994. Oncology Drug Discovery and Clinical Trial Testing Who s Listening Cancer Investigation (New York) 12, no. 1 105-108. 

Oncology Drug Discovery and Preclinical Research, Sanofi Oncology, Vitry-sur-Seine, France... 

Kruse, U., Bantscheff, M., Drewes, G., and Hopf, C. 2008. Chemical and pathway proteomics Powerful tools for oncology drug discovery and personalized health care. Mol. Cell. Proteomics 7(10) 1887-901. 

Drug Discovery Oncology, Nerviano Medical Sciences srl, Nerviano, Italy... 

Severe, life-threatening diseases, such as cancer require a different drug discovery approach. Safety requirements in most oncology targets tolerate more side effects, which otherwise would severely limit the use of a medicine in other indications. For example, in addition to hair loss, a common side effect of cancer treatment, compounds which affect cell cycle, cell proliferation and apoptosis pathways also cause other serious side effects and make the patient endure severe adverse drug reactions (ADRs). 

Reed JC. Apoptosis mechanisms implications for cancer drug discovery. Oncology 2004 18 11-20. 

KM, Naidu BN, et al. Discovery of a fluoroindolo[2,3-a]carbazole 70. clinical candidate with broad spectrum antitumor activity in pre-clinical tumor models superior to the marketed oncology drug, CPT-11. J. Med. Chem. 2005 48 2258-2261. 71. 

TOXICOLOGY/PATHOLOGY CHALLENGES IN THE DISCOVERY OF NEW ONCOLOGY DRUGS... 

The Drug Discovery and Development of Kinase Inhibitors Outside of Oncology... 

---