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Drug discovery cancer

Rylova, SN, Amalfitano, A, Persaud-Sawin, DA, Guo, WX, Chang, J, Jansen, PJ, Proia, AD and Boustany, RM (2002) The CLN3 gene is a novel molecular target for cancer drug discovery. Cancer Res, 62, 801-808. [Pg.165]

Today, 3D databases, which provide the means for storing and searching for 3D information of compounds, are proven to be useful tools in drug discovery programs. This is well exemplified with the recent discovery of novel nonpeptide HIV-1 protease inhibitors using pharmacophore searches of the National Cancer Institute 3D structural database [13-15]. [Pg.106]

Yart A, Mayeux P, Raynal P (2003) Gabl, SHP-2 and Other Novel Regulators of Ras Targets for Anticancer Drug Discovery. Curr Cancer Drug Targets 3 177-192... [Pg.19]

Schrama, D., Reisfeld, R.A., and Becker, J.C. 2006. Antibody targeted drugs as cancer therapeutics. Nature Reviews Drug Discovery 5(2), 147-159. [Pg.417]

Studies using free energy calculations for the design and analysis of potential drug candidates are reviewed in section five. The chapters in this section cover drug discovery programs targeting fructose 1,6-bisphosphatase (diabetes), COX-2 (inflammation), SRC SH2 domain (osteoporosis and cancer), HIV reverse transcriptase (AIDS), HIV-1 protease (AIDS), thymidylate synthase (cancer), dihydrofolate reductase (cancer) and adenosine deaminase (immunosuppression, myocardial ischemia). [Pg.403]

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See also in sourсe #XX -- [ Pg.26 , Pg.27 , Pg.28 , Pg.29 ]

See also in sourсe #XX -- [ Pg.26 , Pg.27 , Pg.28 , Pg.29 ]



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Cancer drugs discovery and development

National Cancer Institute drug discovery/development program

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