Oncogenicity studies

Quast JF, Schuetz DJ, Balmer MF, et al. 1980a. A two-year toxicity and oncogenicity study with acrylonitrile following inhalation exposure of rats. Dow Chemical Co., Toxicology Research Laboratory, Midland Ml. [Pg.117]

Bio/Dynamics. 1995a. An inhalation oncogenicity study of commercial hexane in rats and mice—1. Rats, abridged final report. American Petroleum Institute Publication TR 404 41-33231. [Pg.230]

Hayes RH. 1983. Oncogenicity study of disulfoton technical on mice. Study no. 80-271-04. Mobay Chemical Corporation, Corporate Toxicology Department, Stilwell, Kansas. [Pg.187]

Exxon Biomedical Sciences (1986) Chronic toxicity/oncogenicity study in F-344 Rats. Test Material MRD-83-260. Project No 326075 performed at Exxon Biomedical Sciences, Inc., Unpublished Laboratory Report... [Pg.335]

Oncogenicity studies, therefore, examine the ability of a material to produce neoplastic changes in a tissue or tissues. Short-term gen-otoxicity studies provide a good indicator of oncogenic potential as most oncogenic agents of... [Pg.123]

In Europe, oncogenicity studies will usually be required as part of the development of a pharmaceutical preparation in the following circumstances ... [Pg.124]

Because of their size and duration and the corresponding costs involved, oncogenicity studies... [Pg.124]

The rat will usually be the species of choice for the standard oncogenicity study because there is greater confidence in its predictivity for human carcinogenicity than the mouse or hamster. The species chosen, however, should be the most appropriate based on considerations such as pharmacology, repeated-dose toxicity, metabolism and toxicokinetics. [Pg.125]

Statistically, oncogenicity studies have a low sensitivity because of the small numbers of animals that are used. However, complex statistical analysis, which should include a judgement on whether the tumour was the cause of death, duration to death and trend analysis can reveal valuable information about the risk to man of taking the product therapeutically. [Pg.127]

If oncogenicity studies have been conducted by the oral route and another clinical route is to be used in man, the need to repeat such studies should be assessed critically. Oncogenic potential is related to the concentration of the carcinogen at its site of action. Thus, if the oral route results in adequate exposure of the lung, there should be no need to perform additional inhalation oncogenicity studies. Inhalation studies of 1-3 months duration should be performed to assess possible local effects on respiratory tissue and also to gain pharmacokinetic data. [Pg.138]

Johnson KA, Gorzinski SJ, Bodner KM, et al Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol 85 154-168, 1986... [Pg.26]

DePass LR, Fowler EH, Weil CS Dermal oncogenic studies on various ethyleneamines in male C3H mice. Fundam Appl Toxicol 9 807-811, 1987... [Pg.250]

DePass LR, Carman RH, Woodside MD, et al Chronic toxicity and oncogenicity studies of ethylene glycol in rats and mice. Fundam Appl Toxicoll-.566-512, 1986... [Pg.325]

Wenzel-Hartung RP, Brune H, Klimisch HJ Dermal oncogenicity study of 2-ethylhexyl acrylate by epicutaneous application in male C3H/HeJ mice. J Cancer Res Clin Oncol 115 543-549, 1989... [Pg.335]

Burleigh-Flayer H, Garman R, Neptun D, et al Isopropanol vapor inhalation oncogenicity study in Fischer 344 rats and CD-I mice. Fundam Appl Toxicol 36(2) 95-l 11, 1997... [Pg.414]

Auletta CS, Weiner ML, Richter WR A dietary toxicity/oncogenicity study of tributyl phosphate in the rat. Toxicology 128(2) 125-134, 1998... [Pg.690]

Quast JE Galhoun LL Chlorothene VG A Chronic Inhalation Toxicity and Oncogenicity Study in Rats and Mice. Part II. Results in Rats. Final Report, Feb 5, 1986, pp 1-165. Midland, MI, Mammalian and Environmental Toxicology Research Laboratory, Dow Chemical, 1986... [Pg.694]

Kociba RJ et al Results of a two-year chronic toxicity and oncogenic study of... [Pg.702]

Bogdanffy MS, Tyler TR, Vinegar MB, et al Chronic toxicity and oncogenicity study with vinyl acetate in the rat in utero exposure in drinking water. Fundam Appl Toxicol 23 206-214, 1994... [Pg.729]

Quast JF, McKenna MJ, Rampy LW, et ah Chronic toxicity and oncogenicity study on inhaled vinylidene chloride in rats. Fundam Appl Toxicol 6 105-144, 1986... [Pg.738]

Keyes, D.G, Kociba, R.J., Schwetz, R.W., Wade, C.E., Dittenber, D.A., Quinn, X, Gorzinski, S.J., Hermaim, E.A., Momany, J.J. Schwetz, B.A. (1980) Results of a two-year toxicity and oncogenic study of rats ingesting diets containing dibromoneopentyl glycol (FR1138). [Pg.467]

Mobay Corporation. 1989. Chronic inhalation toxicity and oncogenicity study with attached appendices and cover letter. EPA/OTS doc 86-900000055. (microfiche)... [Pg.175]

R. J. Kociba et al., Results of a 2-Year Chronic Toxicity and Oncogenicity Study of 2,3,7,8- Tetrachlorodibenzo-p-dioxin (TCDD) in Rats, Toxicol. Appl. Pharmacol. 46 (1978) 279-505. [Pg.103]

Quasi, J.F., Humiston, C.G. Wade, C.E., Carreon, R.M., Hermann, E.A., Park, C.N. Schwetz, B.A. (1981) Results of a chronic toxicity and oncogenicity study in rats maintained on water containing acrylonitrile for 24 months (Abstract No. 467). Toxicologist, 1, 129... [Pg.102]

Rampy, L.W. McKenna, M.J. (1984) Methylene chloride a two-year inhalation toxicity and oncogenicity study in rats and hamsters. Fundam. appl. Toxicol., 4, 30-47... [Pg.300]

Burek, J.D., Nitschke, K.D., Bell, T.J., Wackerle, D.L., Childs, R.C., Beyer, J.E., Dittenber, D.A., Rampy, L.W. McKenna, M.J. (1984) Methylene chloride a two-year inhalation toxicity and oncogenicity study in rats and hamsters. Fimdam. appl. Toxicol., 4, 30-47... [Pg.301]

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