Human small intestine oligopeptide transporter 1

In the field of cyclic ANPs, and more particularly (S)-cHPMPA 54 and (S)-cHPMPC 56, amino adds used for the des n of prodrugs has been reviewed by McKenna s group (13MP445). The aim of the introduction of an amino acid promoiety to a cyclic ANP core is to favor oral bioavailability by targeting the human small intestine oligopeptide transporter 1 (hPEPTl). 

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