HPEPTl oligopeptide transporter 1

Brodin, S. Frokjaer, M. Taub, and B. Steffansen. Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepTl in the human intestinal Caco-2 cell line.,... 

Hubatsch, I., Arvidsson, P.I., Seebach, D., Luthman, K. and Artursson, P. (2007) Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepTl. Journal of Medicinal Chemistry, 21, 5238-5242. 

In the field of cyclic ANPs, and more particularly (S)-cHPMPA 54 and (S)-cHPMPC 56, amino adds used for the des n of prodrugs has been reviewed by McKenna s group (13MP445). The aim of the introduction of an amino acid promoiety to a cyclic ANP core is to favor oral bioavailability by targeting the human small intestine oligopeptide transporter 1 (hPEPTl). 

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