Oligomeric structures

There are several important reasons for protein subunits to associate in oligomeric structures. 

Titanium, tetrakis(trimethysilyl)oxy-, 3, 334 Titanium, tetranitrato-stereochemistry, 1,94 Titanium, triaquabis(oxalato)-structure, I, 78 Titanium, tris(acetylacetone)-structurc, 1,65 Titanium alkoxides oligomeric structure, 2,346 synthesis ammonia, 2, 338 Titanium chloride photographic developer, 6,99 Titanium complexes acetylacetone dinuclear, 2, 372 alkyl... 

Zirconium, tetrakis(acetylacetonate)-stereochemistry, 1, 32, 94 Zi rconium, tris(phenylenedithio)-structure, 1, 63 Zirconium alkoxides oligomeric structure, 2,346 Zirconium chloride... 

So far, only for the first two of the six ligand types outlined in Fig. 10 have oligomeric structures with boron been reported. This may be in part due to the relatively small number of publications related to this field and the fact that a systematic attempt to prepare boron macrocycles with these ligands has not been realized so far. 

Thus the picture that emerges at this point is that in the membrane probably a diprotomeric (a) )2 structure (oc is 114 kDa, P is 60-80 kDa) is responsible for the active transport process. On the other hand the minimal structure for K -ATPase activity, K -pNPPase activity, passive transport and phosphorylation is either an otp protomer or another larger oligomeric structure. 

The oligomeric structures of chemokines vary. CXCL8 (IL-8), the prototypical CXC chemokine, is dimeric in solution (26) and in its crystalline form (due to twofold crystallographic symmetry) (27). The three-stranded P-sheet of each subunit joins to form a six-stranded P-sheet (Figure IB). The two C-terminal... 

Much biochemical evidence shows that many if not all 7TM receptors have a strong tendency to aggregate both with themselves and with other 7TM receptors, as most clearly seen in multiple high-molecular-weight bands on sodium dodecyl sulfate (SDS) gels. These bands are by no means restricted to dimers as, in most cases, several higher order oligomeric structures are observed. This is an important point to consider when the functional correlation of dimer formation is addressed in non-family C receptors. 

The pore-forming oq subunit alone is sufficient to form a functional calcium channel in the cell membrane [8]. However, high-voltage-activated calcium channels are hetero-oligomeric structures that may contain as many as three additional smaller subunits, labeled CX25 (itself a heterodimer), (5, and y. These three subunits associate in an auxiliary... 

Lee, L., Kelly, R.E., Pastra-Landis, S.C., and Evans, D.R. (1985) Oligomeric structure of the multifunctional protein CAP that initiates pyrimidine biosynthesis in mammalian cells. Proc. Natl. Acad. Sci. USA 82, 6802-6806. 

Hong M (2006) Oligomeric structure, dynamics, and orientation of membrane proteins from solid-state NMR. Structure 14 1731-1740... 

Hebert, D. N. and Carruthers, A. (1992) Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric, and dimeric GLUT1. J. Biol. Chem. 267, 23829-23838. 

Fig. 3. A gallery of structures representative of the distinct /8-solenoid groups shown in Tables I and II. The /8-solenoid domains are in blue and other domains are in yellow. In the oligomeric structures, only one subunit is colored while the other ones are gray. Small ligand molecules are shown in the ball-and-stick representation and colored magenta.

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