Olfactory bulbectomy

Beauchamp G.K., Magnus J.G., Shmunes N.T. and Durham T. (1977). Effects of olfactory bulbectomy on social behavior of male guinea pigs (Cavia porcellus). J Comp Physiol Psychol 91, 336-346. 

Guthman M.S., Harvey C. and Kling A. (1979). Somato-social development in the Rhesus monkey following olfactory bulbectomy. Primates 20, 211-219. 

Kolunie J. and Stem J. (1995). Maternal aggression in rats — effects of olfactory bulbectomy, ZnS04-induced anosmia, and vomeronasal organ removal. Horm Behav 29, 492-518. 

Gary, D.S., Getchell, T.Y, Getchell, M.L., and Mattson, M.E 2002. Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death. Exp Neurol 176, 266-268. 

Other models include the olfactory bulbectomy model (Song and Leonard, 2005). Lesions of the olfactory bulb cause behavioral changes, inteipreted to result from disturbed function of the limbic system. These behaviors are reversed by chronic antidepressant administration. 

Kairys, D. J., Magalhaes, H., and Floody, O. R., 1980, Olfactory bulbectomy depresses ultrasoimd productirai and scent marking by female hamsters. Physiol. Behav. 25 143-146. 

Brunjes, P.C. 1992. Lessons from lesions the effects of olfactory bulbectomy. Chem. Senses, 17, 729—763. 

Vinkers CH, Breuer ME, Westphal KG, KotIc SM, Costing RS, Olivier B, Groenink L (2009) Olfactory bulbectomy induces rapid and stable changes in basal and stress-induced locomotor activity, heart rate and hody temperature resporrses in the home cage. Nerrroscience 159 39-46... 

Sanchez-Barcelo E., Mediavilla M.D., Sanchez-Criado J.E., Cos S., et al. (1985). Anti-gonadal actions of olfaction and light deprivation effects of blindness and main olfactory bulb — deafferentation and transection of vomeronasal nerve or bulbectomy. J Pineal Res 2, 177-190. 

Didier, A., Jourdan, F. (2002). The Ginkgo biloba extract modulates the balance between proliferation and differentiation in the olfactory epithelium of adult mice following bulbectomy. Cell Mol Biol (Noisy-le-grand), 48, 717-23. 

Interestingly, intact afferent input to PC from the olfactory bulb appears to be required for the initiation of seizures in PC. Olfactory bulb deafferentation (bulbectomy) protects against pilocarpine-induced seizures and increases the dose of KA infused into PC necessary to produce seizures (Millan et al. 1988). 

Another possibility is that the expression of Fos-like immunoreactivity actually does survive in a subset of neurons even after complete bulbectomy. This could be explained if the expression of Fos-like immunoreactivity is developmentally regulated such that it is initially independent of the accessory olfactory bulb but after a certain point in the maturation cycle of receptor neurons becomes dependent upon the bulb. Such young-to-interme-diate stage neurons might constitute the population of immunoreactive receptor neurons that survived bulbectomy. These would be differentiated enough to express Fos-like immunoreactivity independent of connection to the accessory olfactory bulb. 

Costanzo, R.M. Graziadei, P.P. 1983. A quantitative analysis of changes in the olfactory epithelium following bulbectomy in hamster. J.Comp. Neurol, 215, 370-381. 

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