Oleandomycin

Therapeutic Function Antibiotic Chemical Name Oleandomycin see Structural Formula Common Name Troleandomycin Structural Formula  

Chemical Abstracts Registry No. 3922-90-5 Trade Name Manufacturer 

A slant of S. antibioticus ATCC 11891 was cultivated on agar under controlled conditions in order to develop spores for the purpose of inoculating a nutrient medium having the following composition 20 g Cerelose (dextrose hydrate), 15 g soybean meal, 5 g distillers solubles, 10 g cornmeal, and tap water, in a sufficient amount for a 1,000-ml solution, adjusted to pH 7.0 to 7.2 with potassium hydroxide. 

After the pH was adjusted, 5 g of calcium carbonate was added. This inoculum medium was then subjected to heat sterilization. The medium was then cooled and 2 ml of a spore sus- 

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Oleandomycin. Oleandomycin (17, R = CH ) was the primary factor in culture broths of S. antihioticus (69,70). Its aglycone, oleandoHde... 

After seeding the nutrient medium with the preformed inoculum previously described, the mixture was subjected to agitation and aeration under aseptic conditions for 72 hours at 27°C to 28°C for the first 24 hours, then at 25°C to 26°C for the next 48 hours during this period, the pH was in the range of 6.4 to 6.8. Aeration was accomplished by cultivation under submerged conditions at an air flow rate of one volume of air per volume of medium per minute. After termination of the process, the mycelium was removed by filtration and the filtered broth found to contain 450 7of oleandomycin per ml of solution. 

Soybean meal, by fermentation Bacitracin Clavulanic acid Cycloserine Erythromycin Gentamicin sulfate Kanamycin sulfate Micronomicin Novobiocin Oleandomycin Oxamniquine Oxytetracycline Paromomycin Ribostamicin Sisomicin... 

Fig. 15. Cooperative effect of bonding of organic ions on Biocarb-T biosorbent A. 0.1 N NaCl in water B, 0.1 N NaCl in methanol. For l) novocain, 2) oleandomycin and 3) oxytetracycline...

Oleandomycin, its ester (triacetyloleandomycin) and spiran rdn have a similar range of activity as erythromycin but are less active. Resistance develops only slowly in chnical practice. However, cross-resistance may occur between all four members of this group. 

Aguirrezabalaga, I., Olano, C., Allende, N. et al. (2000) Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer. Streptomyces antibioticus. Antimicrobial Agents and Chemotherapy, 44 (5), 1266-1275. 

The most impressive application of 2-thiopyridyl and 2-thiopyrimidinyl donors is in the area of antibiotics. Thus, Woodward et al. [481] successfully completed the total synthesis of erythromycin by using S Pyrm glycoside of D-desosamine and S Pyr-glycoside of L-cladinose as glycosyl donors to the subsequent glycosylation with erythronalide A. This methodology was also successfully used in the synthesis of oleandomycin [482,483], erythromycin A [484] and erythromycin B [485]. 

Old high bloomery furnace, 74 491 Old magazine paper (OMP), 73 128 Old newspaper (ONP), 73 128 pulp from, 73 95-96 Oldshue-Rushton column, 70 778 Oleandomycin, 75 279, 305 derivatives of, 75 282-285t ester derivatives of, 75 281 registered for use in aquaculture in Japan, 3 221t... 

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