Of mimetics

Standards are needed to find M " 1 monolayer of mimetic material 20—40 nm... 

HUNTING OR FOLLOWING EACH OTHER ORIGINS OF MIMETIC SKILLS ... 

Merlin Donald (Origins of the modem mind, 1991) described a phase of mimetic skills in inffahominid primate development. Taking evolutionary psychology seriously and looking back along the line of vertebrates that has led towards man, several steps in mimicking be-... 

Brodie, E. D., Jr. and Brodie, E. D. III. (1980). Differential avoidance of mimetic salamanders by free-ranging birds. Science 208,181-182. 

Simmons, R. B. (2001). Phylogenetic studies of mimetic tiger moths based on... 

The library of mimetics 84 was screened in a radioligand-binding assay against a cloned fMLF receptor. Four compounds corresponding to the contents from the two most active wells were prepared on a larger scale and purified. In both instances, the inhibitory activity was due... 

The area between enzymatic and chemical catalyses, associated with simulation of biochemical processes by their basic parameters, is accepted as mimetic catalysis. The key aspect of the mimetic catalyst is diversity of enzyme and biomimetic function processes, which principally distinguishes the mimetic model from traditional full simulation. Based on the analysis of conformities and diversities of enzymatic and chemical catalysis, the general aspects of mimetic catalysis are discussed. An idealized model of the biomimetic catalyst and the exclusive role of the membrane in its structural organization are considered. The most important achievements in the branch of catalysis are shown, in particular, new approaches to synthesis and study of biomimetic catalase, peroxidase and monooxidases reactions. 

CRITERIA OF MIMETIC CATALYSIS BASED ON CONFORMITIES AND DIVERSITIES BETWEEN ENZYMATIC AND CHEMICAL CATALYSES... 

The basic question of mimetic catalysis is the determination of physicochemical properties of enzymes to be simulated in the synthesized biomimic in accordance with the reaction modeled. Firstly, let us try to answer one of the key questions that arise in biomimic construction how important is it to reach the enzymatic specificity in the synthesis of their analogs To put it another way, should the dynamic (tertiary) structure of the enzyme responsible for the selectivity control mechanism be simulated by active site protection from competitive admixtures This feature of the enzymes distinguishes them from usual catalysts. 

Figure 8.2 shows an electrochemical system - a model of a catalase-biomimetic sensor, consisting of the reference electrode (Ag/AlCl/Cl ) and biomimetic electrode. In this system, the electrochemical potential changed as a result of mimetic electrode interaction with... 

Biomimetic chemistry is a new stage in the development of chemical ideas. In this book, new information on coherent synchronization of chemical and biochemical reactions is developed in the application of achievements of mimetic catalysis. 

Our interest in such methylene acetal derivatives is connected with the design of mimetics of Sialyl Lewis X (sLex) 1, a proposed native ligand for the selectin family of cell adhesion molecules. sLex-selectin interactions have been... 

Mlmetlcs Compounds that share the desired properties of other molecules (e.g.. the affinity for a given receptor) but do not share the undesirable properties, such as sasccpiibility to proteases. An important class of mimetics is peptide miinctics. 

Intensive work worldwide on the design of renin inhibitors has yielded several classes of potent compounds. Most of these inhibitors are transition-state mimetics of the P -P scissile bond (Fig. 2) combined with peptide residues or analogues thereof [1], Much work has been focused on the minimization of the peptide character of renin inhibitors to overcome the drawbacks of substrate-analogous peptides, such as the instability towards enzymatic cleavage, biliary excretion, and low oral bioavailability. In the course of our studies on renin inhibitors at Roche, we synthesized a series of mimetics incorporating the P4-P3 binding elements [2, 3]. 

N-Heterocycles in the synthesis of mimetics of polypeptides of /J-hairpin group as reagents for drug and vaccine discovery 00SL429. 

Synthetic zeolite NaPl (or Linde B) is apparently an isotype of gismondine (Figure 14) according to a recent study by Baerlocher and Meier (4). The cubic structure which was proposed earlier has been ruled out in this work. The symmetry of the NaPl framework is noncubic (despite the fact that the unit cell is compatible with cubic symmetry), and the phase appears to consist of mimetic twins. 

In order to use this template approach in view of synthesising combinatorial libraries of mimetics of exposed protein loops, Waldmeier and Obrecht synthesised the unsymmetrically substituted xanthene derived templates 11 and 12 Figure 23.6)P... 

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