Pseudopeptide mimetic analog of insect neuropeptides

NACHMAN ET AL. Pseudopeptide Mimetic Analogs of Insect Neuropeptides 211... 

NACHMAN ETAL. Pseudopeptide Mimetic Analogy of Insect Neuropeptides 229... 

In this paper, we discuss pseudopeptide mimetic analogs that have been developed for selected insect neuropeptide families, including the insect kinins, sulfakinins, myosuppressins, and insect tachykinins. First members of these families were isolated from the cockroach or locust on the basis of their ability to either stimulate or inhibit contractions of the isolated cockroach/hindgut. Subsequently, these peptide families have been found in a range of insect species and associated with a variety of different physiological responses. The paper closes... 

In the future, knowledge of the active conformational or 3-dimensional shape requirements for neuropeptide-receptor interaction can help to expand upon the progress that has been achieved in insect neuropeptide analog development, and aid in the design of pseudopeptide and non-peptide mimetic analogs of even greater potency. Some of these analogs may have the potential to disrupt critical insect processes. 

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