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Oestrogen receptors

It is not certain that all the effects of DES can be ascribed to its oestrogenic activity (that is to say, directly related to its ability to bind to the oestrogen receptor), but it would appear from experience with this compound that rodent assays are able to detect the relevant toxicological effects. What then was the... [Pg.2]

More subtle modes of action are also possible since the response to hormone receptor binding is complex and could be affected by chemical interference with receptor-related proteins, DNA methylation or histone acetylation. Dioxin (TCDD), for example, reduces the ability of the oestrogen-receptor complex to bind to the oestrogen response element of DNA, reducing gene transcription. ... [Pg.12]

The responsiveness of a tissue to a hormone depends on the density of receptors within its component cells. The number of receptors is determined by their rate of synthesis and catabolism, which is itself controlled by complex feedback mechanisms involving hormone action. Some chemicals are known to interfere with this regulation. For example, TCDD can act to increase or decrease the expression of the oestrogen receptor. ... [Pg.13]

Oestrogen receptor binding/Reporter gene assay. [Pg.18]

Selective oestrogen receptor modulators (SERMs, e.g. Raloxifene) Calcitriol and analogues (limited use)... [Pg.280]

Jordan VC (2007) Chemoprevention of breast cancer with selective oestrogen-receptor modulators. Nat Rev Cancer 7 46-53... [Pg.1117]

ISSA J p, OTTAVIANO Y L, CELANO P, HAMILTON S R, DAVIDSON N E and BAYLIN S B (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon , Nat Genet, 1, 536-40. [Pg.41]

PATISAUL H B, WHITTEN p L, YOUNG L J (1999) Regulation of oestrogen receptor beta mRNA in the brain opposite effects of 17beta-oestradiol and the phytoestrogen, coumestrol. Brain Res Mol Brain Res. 67 165-71. [Pg.84]

PATISAUL H B, DiNDO M, WHITTEN p L, YOUNG L J (2001) Soy isoflavone Supplements antagonize reproductive behavior and oestrogen receptor alpha- and beta-dependent gene expression in the brain. Endocrinol. 142 2946-52. [Pg.84]

SAUNDERS P T, SHARPE R M, WILLIAMS K, MACPHERSON S, URQUART H, IRVINE D S, MILLAR M R (2001) Differential expression of oestrogen receptor alpha and beta proteins in the testes and male reproductive system of human and non-human primates. Mol Hum Reprod. 7 227-36. [Pg.85]

Ali S, Metzger D, Bornert JM, Chambon P (1993) Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region. EMBOJ 12 1153... [Pg.56]

Brzozowski AM, Pike AC, Dauter Z (1997) Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389 753... [Pg.56]

Green S, Walter P, Kumar V, Krust A, BornertJM, Argos P, Chambon P (1986a) Human oestrogen receptor cDNA sequence, expression and homology to v-erb-A. Nature 320 134... [Pg.57]

King WJ, Greene GL (1984) Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells. Nature 307 745... [Pg.58]

Ponglikitmongkol M, Green S, Chambon P (1988) Genomic organization of the human oestrogen receptor gene. EMBO J 7 3385... [Pg.60]

Welshons WV, Lieberman ME, Gorski J (1984) Nuclear localization of unoccupied oestrogen receptors. Nature 307 747... [Pg.61]

Sutherland RL, Murphy LC, San Foo M, Green MD, Whybourne AM, Krozowski ZS (1980) High-affinity anti-oestrogen binding site distinct from the oestrogen receptor. Nature 288(5788) 273-275... [Pg.114]

Butler JA, Sjoberg M, Coen CW (1999) Evidence for oestrogen receptor a-immunoreactivity in gonadotrophin-releasing hormone-expressing neurones. J Neuroendocrinol 11 331-335... [Pg.140]

Guerra B, Diaz M, Alonso R, Marin M (2004) Plasma membrane oestrogen receptor mediates neuroprotection against /3-amyloid toxicity through activation of Raf-1/MEK/ERK cascade. J Neurochem 91 99-109... [Pg.143]

Legan SJ, Tsai HW (2003) Oestrogen receptor-alpha and beta immunoreactivity in gonadotropin-releasing hormone neurons after ovariectomy and chronic exposure to oestradiol. J Neuroendocrinol 15 1164-1170... [Pg.144]

Pappas TC, Gametchu B, Yannariello-Brown J, Collins TJ, Watson CS (1994) Membrane oestrogen receptor in GH3B6 cells are associated with rapid oestrogen-induced release of prolactin. Endocrine 2 813-822... [Pg.147]

Pelletier G, Labrie C, Labrie F (2000) Localization of oestrogen receptor a, oestrogen receptor and androgen receptors in the rat reproductive organs. J Endocrinol 165 359-370... [Pg.147]

Saunders PTK, Maguire SM, Gaughan J, Millar MR (1997) Expression of oestrogen receptor beta (ERbeta) in multiple rat tissues visualised by immunohistochemistry. J Endocrinol 154 R13-R16... [Pg.148]

See other pages where Oestrogen receptors is mentioned: [Pg.3]    [Pg.12]    [Pg.17]    [Pg.73]    [Pg.77]    [Pg.93]    [Pg.102]    [Pg.114]    [Pg.115]    [Pg.121]    [Pg.121]    [Pg.132]    [Pg.280]    [Pg.280]    [Pg.284]    [Pg.82]    [Pg.838]    [Pg.18]    [Pg.217]    [Pg.217]    [Pg.217]    [Pg.217]    [Pg.219]    [Pg.219]    [Pg.236]    [Pg.144]    [Pg.148]   
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Oestrogen

Oestrogen receptor antagonists

Oestrogen receptor binding

Oestrogen receptor genes

Oestrogen receptor modulators

Selective oestrogen receptor

Selective oestrogen receptor modulators

Selective oestrogen receptor modulators SERMs)

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