Oct-3/4 protein

The origin and identity of NSCs remain source of debate and controversy [1]. Though recent reports further support an astroglial origin for newly-generated neuronal cells [25-29], NSCs are yet to be unequivocally identified in the adult brain. There are currently no specific markers of adult NSCs. The intermediate neurofilament nestin, the transcription factors sox-2, oct-3/4, and the RNA binding protein Musashi 1 are markers for neural progenitor and stem... 

A key regulatory protein called Oct-3/4, a transcription factor protein, is involved in the determination of the development of ES cells. 

Niwa H, Miyazaki J, Smith A G (2000). Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24 372-376. Chambers I, Colby D, Robertson M, et al. (2003). Eunctional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 113 643-655. Ying Q L, Nichols J, Chambers I, et al. (2003). BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell. 115 281-292. 

Protein level Surface marker analysis Immunohistochemical analysis Oct-4, Oct-3/4, Nanog, TRA-1-60, Tra-1-81, SSEA-3, SSEA-4 Oct3/4, Oct-4, Sox-2, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, Nanog Alkakine phosphatase(AP)... 

Simultaneous Detection of Oct 4 mRNA and -Galactosidase Protein on Paraffin Sections... 

Table 2.1.9 Changes of blood amino acids in various primary inherited defects and as a result of secondary changes. ASA Argininosuccinic acid, CPS carbamoyl phosphate synthase, LPI Lysinuric protein intolerance, MAD multiple acyl-CoA dehydrogenation, MSUD maple syrup urine disease, NAGS N-acetylglutamate synthase, NKH nonketotic hyperglycinemia, NTBC 2-(2-nitro-4-3 trifluoro-methylbenzoyl)-1,3-cyclohexanedione, OCT Ornithine carbamoyltransferase,...

An interesting biological system which contains Fe in an [Fe(III)-On] coordination structural environment is the iron-storage protein, ferritin. The core of ferritin consists of a phosphate-containing, iron (III) hydrated oxide or oxide-hydroxide (2). Models have been suggested for the ferritin core which feature Fe(III) in [Fe(III)04]tet (3), [Fe(III)-Oeloct (4), and mixed [Fe(III)04]ter-[Fe(III)06]oct (5) coordination environments. 

Heat treatment of eggs by cooking and frying creates a variety of other volatile compounds, more from egg yolk than from egg white. The main volatile components are aldehydes, alcohols, free fatty acids, esters and other compounds. Those occurring in the highest quantities are (2Z,4Z)- and (2Z,4E)-deca-2,4-dienals, (Z)-oct-2-enal, nonanal, hexanal, phenylacetaldehyde and hexyl butyrate. Egg white odour resembles (2E,4Z,7Z)-2,4,7-tridecatrienal, which arises as a product of arachidonic acid autoxidation (see Section 3.8.1.12.1). Its odour threshold was estimated to be 0.07ng/1 air. Sulfane and ammonia are also important protein degradation products. 

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