Nutritional intervention trials

Li JY Taylor PR, Li B, et al. Nutrition intervention trial in Linxian, China multiple vitamin/mineral supplementation, cancer incidence, and disease specific mortality among adults with esophageal displasia. J Natl Cancer Inst 1993 85 1492-1498. 

Bll. Blot, W. J., Li, J. Y., Taylor, P. R., Guo, W., Dawsey, S., et al., Nutrition intervention trials in Linxian, China. Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. Natl. Cancer Inst. 85, 1483-1492 (1993). 

Blot, W. J. et al.. Nutrition intervention trials in Linxian, China supplementation with specific... 

Von Berg, A., Koletzko, S., Grubl, A., et al. (2003). The effect of hydrolyzed cow s milk formula for allergy prevention in the first year of life The German Infant Nutritional Intervention Study, a randomized double-blind trial.. Allergy Clin. Immunol. Ill, 533-534. 

Fewer than 20 years ago high-dose zinc supplementation was reported to reduce significantly the risk of vision loss in a short-term study that lacked a control arm. Since then, nutritional interventions have become popular with researchers as well as the general public. Unfortmiately, subsequent trials have felled to substantiate this initial result. 

K/DOQI Kidney Dialysis Outcomes and Quality Initiative MAP mean arterial blood pressure MDRD Modification of Diet in Renal Disease MRFIT Multiple Risk Factor Intervention Trial NHANES III Third National Health and Nutritional Examination Survey... 

Despite the high incidence of malnutrition pre-OLT, data supporting a mortality benefit from pre-OLT nutrition support are relatively lacking. Studies thus far have been limited by small sample size, so it is uncertain whether nutritional interventions in these patients truly convey a survival benefit long term. Larger controlled clinical trials are needed. 

Yu SY, Zhu YJ, Li WG, et al. 1991. A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China. Biol Trace Elem Res 29(3) 289-294. 

Table 2 Clinical Trials with Prebiotic Oligosaccharides in Term Infants (Nutritional Intervention During the First Year of Life)...

The number of papers published in the field of nutritional metabo-lomics has increased rapidly over the past few years. While a detailed literature review of all papers is beyond the scope of this chapter, a more focused overview of some of the studies using functional ingredients will be presented. There are a number of studies which have investigated the effects of pol henols on metabolic effects in humans. Grun and colleagues developed a GC-MS metabolomis method to profile phenolic microbial fermentation products (Gmn et al. 2008). They successfully applied this in a cross-over human intervention trial where... 

Dolecek, T.A. and Granditis, G. 1991. Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial (MRFIT). World review of nutrition and dietetics, 66, 205-16. 

Stamler J, Caggiula AW, Cutler JA et al. (1997) Dietary and nutritional methods and findings The Multiple Risk Factor Intervention Trial (MRFIT). American Journal of Clinical Nutrition 65(1 supplement) 183S 02S. 

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