Nucleic acid binding

Helicase has also been a focal point for the development of antiviral chemotherapy of the coronavirus associated with severe acute respiratory syndrome (SARS) in humans. Although several experimental compounds with nucleic acid binding activity showing effective inhibition of SARS-CoV helicase were reported in 2005, there have been no reports of any further development since that time (Kesel 2005). It remains to be seen whether the S ARS-CoV compounds will be developed further, especially since no new infections have been observed in recent years. 

The general topology of rubredoxins is also observed in the general zinc-ribbon motif in RNA polymerases or in transcription factors (59). The first published zinc-ribbon structure was that of the nucleic-acid binding domain of human transcriptional elongation factor TFIIS (PDB file ITFI) 40). These zinc binding domains and rubredoxins... 

Bentin T., Nielsen P. E. Enhanced peptide nucleic acid binding to supercoiled DNA possible implications for DNA breathing dynamics. Biochemistry 1996 35 8863-8869. 

The orthogonally-protected Cys moiety thus serves as a convenient handle that can be used to link aPNA modules together in order to expand its nucleic acid binding capability and/or attach molecular probes. 

Protoberberine Alkaloids Physicochemical and Nucleic Acid Binding Properties 157... 

Maes BUW (2006) Transition-Metal-Based Carbon-Carbon and Carbon-Heteroatom Bond Formation for the Synthesis and Decoration of Heterocycles. 1 155-211 Maiti M, Kumar GS (2007) Protoberberine Alkaloids Physicochemical and Nucleic Acid Binding Properties. lO. 155-210... 

Maiti and Kumar, in their contribution, review the physicochemical and nucleic acid binding properties of several isoquinoUne alkaloids (berberine, palmatine and coralyne) and their derivatives imder various environmental conditions. 

Malina, A., Khan, S., Carlson, C. B., Svitkin, Y., Harvey, I., Sonenberg, N., Beal, P. A., and Pelletier, J. (2005). Inhibitory properties of nucleic acid-binding ligands on protein synthesis. FEBS Lett. 579, 79-89. 

Their dihydrodiol precursors are only isolable in tiny quantities, insufficient for complete investigations of their biological and nucleic acid binding properties. 

---