Platinum compounds, nucleic acid

Recent reviews in the field of platinum anticancer drugs focus on platinum-nucleobase chemistry [7], biological processing of platinum-modified DNA [8], trans-platinum anticancer drugs [5], cisplatin and derived anticancer drugs [4,9], proteins and cisplatin [10], trans-diam-mineplatinum(II) and nucleic acids [11], and catalytic activity and DNA [12], just to mention a few. The aim of this review is to explore the chemistry in the interaction of various platinum compounds with nucleic... 

Richmond TJ, Widom J (2000) Nucleosome and chromatin structure. Oxford University Press, Oxford Roberts JJ, Thomson AJ (1979) The mechanism of action of antitumor platinum compounds. Prog Nucleic Acid Res Mol Biol 22 71-133... 

Additionally, nucleic acid bases have been used in the dynamic assembly of mixed-metal, mixed-pyrimidine metallacalix[n]arenes [47]. In this approach, Lippert and coworkers investigated the dynamic assembly of metallacalixarenes based on platinum (Pt ), palladium (Pd°), uracil, and cytosine assemblies with mixed amines. These combinations form cyclic metallacalix[n]arenes structures with n = A and = 8. Of the metallacalix[4]arenes, compounds were formed with five, six, and eight bonded metals, and a variety of nucleobase coimecfivities (UCUC and UCCU). The dynamic nature of this assembly allows access to novel and structurally diverse set of nucleobase metallacalixarenes. 

Nucleic acids - [NUCLEIC ACIDS] (Vol 17) -in cell culture products [CELL CULTURE TECHNOLOGY] (Vol 5) -coordination compounds as probes [COORDINATION COMPOUNDS] (Vol 7) -electrophoresis of [ELECTROSEPARATIONS - ELECTROPHORESIS] (Vol 9) -phosphorus m [MINERALNUTRIENTS] (Vol 16) -role m sterilization [DISINFECTANTS AND ANTISEPTICS] (Vol 8) -ruthenium cmpds as probes [PLATINUM-GROUP METALS, COMPOUNDS] (Vol 19)... 

Binding of Platinum Compounds to Monomeric Nucleic Acid Fragments. 65... 

Spectroscopic and crystallographic studies of platinum-base complexes give some insight into the reactivity of the platinum compounds and their possible binding sites on DNA. The reactions of the different nucleosides or nucleotides with the chloro and aquo derivatives of O Cs- and trans-DDP have been studied by UV spectroscopy (36), raman difference spectrophotometry (37) and high pressure liquid chromatography (38). For both chloro isomers, the rates of the reactions with various nucleic acid monomers show the following trend GMP > AMP > CMP and dG > dA > dC T, The dichloro and diaquo derivatives react slowly with thymidine and UMP (37) or not at all (38, 39). 

Pt(dien)Cl]Cl. We have first investigated the Pt(dien)-DNA adducts because monofunctional fixation of platinum on DNA was expected to be simpler than bidentate fixation. In addition, complexes of [Pt(dien)Cl]Cl with nucleic acid bases which could serve as model compounds for the identification of the Pt(dien)-DNA adducts have been previously synthesized and well characterized. 

Due to the anticancer activity of some amine-coordinated Pt compounds, there has been extensive interest in the complexes of Pt with oligonucleotides and nucleotides. These Pt complexes normally have square planar geometry and, in the case of bases and dinucleotides, can template more extensive supramolecular structures. Certain cw-Pt complexes are highly effective anticancer agents, the most famous being cisplatin or d5-diamminedichloroplatinum(II) and a related compound, carboplatin, cM-diammine(cyclobutane-l,l-dicarboxylato)platinum(II). There have been extensive studies of the coordination properties of Pt compounds with nucleic acid bases to further understand the effect of these drugs on DNA structure and function. ... 

Roberts, J. J. Thomson, A. J., The Mechanism of Action of Antitumor Platinum Compounds, Prog. Nucleic Acid Res. Mol. Biol., 1978, 71. 

J. J. Roberts and A. J. Thomson, The mechanism of action of antitumor platinum compounds, Progress in Nucleic Acid Research and Molecular Biology, vol. 22, pp. 71-133, 1979. 

Finally, the appearance of more reviews of platinum-containing anticancer agents reflects the enormous amount of work devoted to this sub-ject. Features of chemical interest in them include the effects of leaving group (in substitutions), solubility and electronic charge, and the nature of the binding of platinum compounds to nucleic acids. 

Brabec, V., DNA modifications by antitumor platinum and ruthenium compounds Their recognition and repair. In Progress in Nucleic Acid Research and Molecular Biology, Vol 71, ed. Ed. Eds. 2002 Vol. 71,... 

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