Nucleic acids metals

T.G. Spiro, Nucleic Acid-Metal Ion Interactions (John Wiley Sons, New York, 1980). 

Norden B, Matsuoka Y, Kurucsev T. 1986. Nucleic acid-metal interactions V. The effect of silver (I) on the structures of A- and B-DNA forms. Biopolymers 25 1531 -1545. 

Rosenberg, B. in Nucleic Acid Metal ion interactions, (ed. Spiro, T. G.), Wiley, New York 1980... 

Marzilli LG, Kistenmacher TJ, Eichhorn GL (1980) Nucleic acid - metal ion interactions, John Wiley and Sons, New York, USA... 

In the biologically relevant, usually monodentate, ademne " " (238) and related ligands (239-241), it is often difficult in deciding if binding takes place at the N-1 or N-7 sites, and it is possible that the binding position for adenine may be metal ion specific Ni°, Cu , Co°, Cd at N-7 Zn at both Hg and at N-1 (see Nucleic Acid-Metal Ion Interactions). 

Biomineralization Calcium-binding Proteins Metal Ion Toxicity Metal-mediated Protein Modification Metalloreg-ulation Nucleic Acid-Metal Ion Interactions Nutritional Aspects of Metals Trace Elements. 

The ability to calculate redox potentials has powerfid implications. For example, elecfrocatalytic reactions of metal complexes, such as Ru(bpy)3 +, with DNA nucleobases, such as guanine, provide a sensitive method for detection of nucleic acids on surfaces in electrochemical DNA chips (see Nucleic Acid-Metal Ion Interactions) In these reactions, voltammetric oxidation of Ru(bpy)3 + to Ru(bpy)3 + in the presence of guanine produces an enhancement in the oxidative current due to the reaction of Ru(III) with guanine (Figure 2). On surfaces, the extent of elecfrocatalytic enhancement is indicative of the quantity of bound nucleic acid levels of DNA as low as 40 attomoles have been detected using related methods. ... 

Metal ions are usually required to promote and stabilize functionally active or native conformations of nucleic acids, as well as to mediate nucleic acid-protein interactions. However, metal ions can also cause structural transformation of nncleic acids, or denature their native structures. In addition to structural roles, some metal compounds can indnce cleavage (i.e. scission, fragmentation, or depolymerization) and modification (withont cleavage) of nucleic acids. Metal-nucleic acid interactions can be either nonspecific or dependent on the chemical nature of nucleotide residues, nucleic acid sequence, or secondary and/or tertiary structure of nucleic acids. The specificity of these interactions is dependent... 

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