Interaction of Nucleic Acids with Metals

Traditionally this area has been dominated by studies involving platinum complexes although more recently there has been considerable interest in the use of ruthenium and rhodium 

Rh(phi)2bpy and Rh(phen)2phi are known to induce efficient nucleic acid strand cleavage 

The metal complex Ru(phen) exists in two enantiomeric frums A and A both enantiomers bind DNA although their structural binding characteristics have remained unclear. Two-dimensional nmr expmments have demonstrated that both enantiomers bind to the minor groove of the AT region in the self-complementary duplex d(CGCGATCXjCG)]2. An octahedral ruthenium(II) complex (292) of the alkaloid 2-bromoleptoclinidinone has been prepared and 

The adduct formed by platination of d(AGA) with a monodentate platinum complex 

1 1 complexes with the 2 -deoxyribonucleotide 5 -monoidiosphates of guanine, adenine, cytosine and thymine. There ajqiears to be little selectivity in the complexation and Watson-Crick hydrogen bonds are not disrupted by die process. Molecular modelling studies with oligo- 

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Interactions of Nucleic Acids with Metal Ions... 

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