Nucleic acids genetic mutations

Myal Y., Blanchard A., Watson P., CoRRiN M., Shiu R., Iwasiow B. Detection of genetic point mutations by peptide nucleic acid-mediated polymerase chain reaction clamping using paraffin-embedded specimens. Anal. Biochem. 2000 285 169-172. 

There is always interest in the photochemistry of the pyrimidine nucleic acid bases and related simple pyrimidinones, due to its importance in genetic mutation. In addition to damaging DNA, photo-induced reactions may also repair the damage, as in the reduction, by FADH, of the thymine glycol 64 back to thymine <06JACS10934>. Another report related to repair of DNA involved a model study, by means of the linked dimer 65, of the involvement of tryptophan in the electron-transfer leading to reversion of thymine oxetane adducts <06OBC291>. 

Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. [NIH]... 

Zhang, Y, Coyne, M.Y, WUl, S.G., Levenson, C.H., and Kawasaki, E.S., Single-base mutational analysis of cancer and genetic diseases using membrane bound modified oligonucleotides. Nucleic Acid Res., 19(14), 3929-3933, 1991. 

Goldstein DB (2001) Islands of linkage disequilibrium. Nat Genet 29 217-222 Haliassos A, Chomel JC, Tesson L, Baudis M, Kruh J, Kaplan JC, Kitzis A (1989) Modification of enzymatically amplified DNA for the detection of point mutations. Nucleic Acids Res 17 3606... 

J. Wakai, A. Takagi, M. Nakayama, T. Miya, T. Miyahara, T. Iwanaga, S. Takenaka, Y. Ikeda and M. Amano, A novel method of identifying genetic mutations using an electrochemical DNA array, Nucleic Acids Res., 32 (2004) el41. 

Genetic mutations and altered nucleic acid integrity Chromosomal breaks, nondisjuction, mitotic interference Diminished supplies of precursors and substrates Altered energy sources Altered osmobalance Enzyme inhibition... 

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