Nuclear factor kappa-light-chain-enhancer

NF-kB (nuclear factor kappa-light-chain-enhancer of activated B-cells) is a protein complex that acts as a transcription factor. It is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, UV radiation, oxidised lipoproteins and bacterial or viral antigens. It plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-/cB has been linked to cancer, inflammatory and automunune disease, septic shock, viral infection and improper immune development. 

NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells... 

NE-kB Nuclear factor kappa-light-chain-enhancer of activated B cells NHANES National Health and Nutrition Examination Survey NNK 4-(N-methyl-N-nitrosamino)-1 -(3-pyridal)-1 -butanone... 

GRAS generally recognized as safe, PGE2 prostaglandin E2, TNF tumor necrosis factor, IL interleukin, NF-kB nuclear factor kappa-light-chain-enhancer of aetivated B cells... 

NF-kB (nuclear factor-kappa B) is a transcription factor so named because its first identified binding site is located within an enhancer in the Ig k light chain gene in mature B cells. The functional NF-kB is a homo- or heterodimer of homologous proteins that share a common structure motif called the Rel domain. The Rel family in the vertebrate includes five cellular proteins p50 (NF-kB 1), p52 (NF-kB2), p65 (RelA), RelB, and c-Rel. The most common NF-kB consists of a p65 p50 heterodimer, but there exists a variety of homodimers and heterdimers, each of which activates its own characteristic set of genes. 

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