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Nrf2 transcription factor

Ramos-Gomez, M., M. K. Kwak, P. M. Dolan et al. 2001. Sensitivity to carcinogenesis is increased and chemo-protective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98(6) 3410—3415. [Pg.433]

Casalino E, Calzaretti G, Landriscina M, Sblano C, Fabiano A, Landriscina C (2007) The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats comparison with the toxic effect on NAD(P)H quinone reductase. Toxicology 237(l-3) 24-34. doi 10.1016/j. tox.2007.04.020... [Pg.451]

Leung, L., M. Kwong, S. Hou, C. Lee and J.Y. Chan. Deficiency of the Nrfl and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J. Biol. Chem. 278 48021-48029,... [Pg.222]

A. L. Slitt, N. J. Cherrington, M. Z. Dieter, L. M. Aleksunes, G. L. Scheffer, W. Huang, D. D. Moore, C. D. Klaassen, Trans-stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors. Mol. Pharmacol. 69 (2005) 1554. [Pg.73]

HepG2 cells p38 blockage restored the inhibited Nrf2 transcription factor and the enzymatic expression and activity of antioxidant enzymes increased GSH content, activity of glutathione peroxidase, glutathione reductase and GCS and glutathione-Stransferase. [80] ... [Pg.243]

Chronic kidney disease (CKD) in type 2 diabetes mellitus patients Regulates transcription factor Nrf2 Phase II Reata Pharmaceuticals 695... [Pg.69]

Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, Yamamoto M. 2000. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275 16023-16029. [Pg.260]

Hsieh TC, Lu X, Wang Z, Wu JM. 2006. Induction of quinone reductase NQOl by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2. Med Chem 2 275-285. [Pg.353]

Brown SL, Sekhar KR, Rachakonda G, Sasi S, Freeman ML. 2008. Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway. Cancer Res 68 364-368. [Pg.420]

Kwak MK, Itoh K, Yamamoto M, Kensler TW. 2002. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents Role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol 22 2883-2292. [Pg.422]

Theodore M, Kawai Y, Yang J, Kleshchenko Y, Reddy SP, Villalta F, Arinze IJ. 2008. Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2. J Biol Chem 283 8984—8994. [Pg.424]

Calabrese V, Ravagna A, Colombrita C, Guagliano E, Scapagnini G, Calvani M, Butterfield DA, Giuffrida Stella AM. 2005. Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress Involvement of the transcription factor Nrf2. J Neurosci Res 79 509-521. [Pg.445]

In rodents and in human cells, the transcription factor, Nrf2, can be activated by phenolic antioxidants to bind to the antioxidant response element (ARE), thereby enhancing transcription of genes encoding Phase II enzymes including GST-1 and NQOl (14,175,176). [Pg.185]

Ma Q, Kinneer K, Bi Y, Chan JY, Kan YW. Induction of murine NAD(P)H quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction. Biochem J 2004 377 205-213. [Pg.202]

Figure 13.12. The Nrf family and Maf family transcription factors. The basic domain is involved in DNA binding and the leucine zipper domain is a dimerization module with other basic-leucine zipper transcription factors. Small Maf proteins such as MafK and MafG het-erodimerize with Nrf2 for binding and activation of the ARE. Figure 13.12. The Nrf family and Maf family transcription factors. The basic domain is involved in DNA binding and the leucine zipper domain is a dimerization module with other basic-leucine zipper transcription factors. Small Maf proteins such as MafK and MafG het-erodimerize with Nrf2 for binding and activation of the ARE.
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See also in sourсe #XX -- [ Pg.254 , Pg.255 , Pg.410 ]



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Nrf2 transcription factor modification

Nrf2 transcription factor transcriptional activity

Transcription factor

Transcriptional factor

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