Nrf2 transcription factor transcriptional activity

Figure 13.12. The Nrf family and Maf family transcription factors. The basic domain is involved in DNA binding and the leucine zipper domain is a dimerization module with other basic-leucine zipper transcription factors. Small Maf proteins such as MafK and MafG het-erodimerize with Nrf2 for binding and activation of the ARE.

Moi P, Chan K, Asunis I, Cao A, Kan YW. 1994. Isolation of NF-E2 related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the /3-globin locus control region. Proc. Natl. Acad. Sci. USA 91.9926-30... 

A number of mechanistic questions remain regarding the individual proteins that participate in the EPRE binding complex, their interactions with other signaling pathways, and the influence of tissue-specific or developmental stage-specific factors. Further utilization of the zebrafish model system will prove to be a powerful tool for the identification of accessory factors that may influence the transcriptional activity of Nrf2 and for investigating the toxic mechanisms of electrophiles, which activate... 

HepG2 cells p38 blockage restored the inhibited Nrf2 transcription factor and the enzymatic expression and activity of antioxidant enzymes increased GSH content, activity of glutathione peroxidase, glutathione reductase and GCS and glutathione-Stransferase. [80] ... 

Brown SL, Sekhar KR, Rachakonda G, Sasi S, Freeman ML. 2008. Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway. Cancer Res 68 364-368. 

In rodents and in human cells, the transcription factor, Nrf2, can be activated by phenolic antioxidants to bind to the antioxidant response element (ARE), thereby enhancing transcription of genes encoding Phase II enzymes including GST-1 and NQOl (14,175,176). 

Leonard MO, Kieran NE, Elowell K, Burne MJ, Varadarajan R, Dhakshinamoorthy S, Porter AG, O Farrelly C, Rabb El, and Taylor CT. Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J 20 2624-2626,2006. 

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