Notch Signaling with Protease Participation

Proteolytic cleavage of the Notch receptor occurs in the vicinity of its transmembrane section. It is imclear which protease is involved in this processing and how the protease is activated by hgand binding. 

The Notch signaling pathway is thus a further example of signal conduction in which the signal is directed by the shortest pathway from the cell membrane into the nucleus. 

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