Notch repeats

To weigh an object, place the unknown object on the center of the balance pan. Move the heaviest weight over, a few notches at a time, until the beam side is heavier than the pan side. Move that weight back one notch, then take the next heaviest weight and slide it over, a few notches at a time, until the beam side is again heavier than the pan side. Move that weight back one notch. Repeat this process for all of the weights on notched beams. 

When using a triple-beam balance, place an object on the pan. Slide the largest rider along its beam until the pointer drops below zero. Then move it back one notch. Repeat the process for each rider proceeding from the larger to smaller until the pointer swings an equal distance above and below the zero point. Sum the masses on each beam to find the mass of the object. Move all riders back to zero when finished. 

The Drosophila Notch 1 is a 300-kDa integral membrane protein that contains 36 EGF-like repeats. 

The notch/ankyrin repeats are evolutionarily conserved structural modules... 

Notch. The notch gene in Drosophila encodes a receptor-like transmembrane protein with EGF-like repeats. Notch is essential for ectoderm differentiation. 

Alternative substrates may exist for the PHDs proposed examples include RNA polymerase II and IkB kinase-P (which is negatively regulated by PHDl) (115, 116). However, unequivocal evidence (e.g., demonstration of hydroxylation by mass spectrometry) has not yet been demonstrated for these proteins. In contrast, FIH has been shown to catalyze hydroxylation of ankyrin repeat domain (ARD) proteins from the NFkB (nuclear factor kB) and Notch family at highly conserved as-paraginyl residues (117, 118). The ARD is a common protein motif, with over 200 human members of the ARD protein family being predicted. Evidence that ARD hydroxylation occurs frequently in human cells supports the assertion (117, 118) that posttranslational hydroxylation of cytoplasmic proteins in... 

DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. As- 137. paraginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J. Biol. Chem. 2007 282 24027-24038. 

Any unit, structure or component that is subject to vibration or other repeated stresses in the presence of a notch. 

Fatigue progresses at the base of a notch in three stages (1) Stress concentration (2) Cracks initiate under repeated stresses ... 

Both Notch and its ligand Delta are transmembrane proteins with numerous EGF-like repeats in their extracellular domains. They participate in a highly conserved and important type of cell differentiation in both Invertebrates and vertebrates, called lateral inhibition, in which adjacent and devel-opmentally equivalent cells assume completely different fates. This process, discussed in detail In Chapter 15, is particularly important in preventing too many nerve precursor cells forming from an undifferentiated layer of epithelial cells. 

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