Ankyrin repeat domains

I/cBa substrate peptide (Figure 7.11). These isolated j5-catenin and I/cBa peptides should accurately reflect the context of these destruction motifs in their respective full-length proteins, since Lysl9 and the destruction motif of j5-catenin are both in a 133-residue N-terminal region that has been previously shown to have a disordered structure by proteolytic digestion analysis [104]. The destruction motif of I/cBa similarly resides outside the structured ankyrin-repeat domain. 

Cohen, S., Orian, A., and Ciechanover, A. (2001). Processing of pl05 is inhibited by docking of p50 active subunits to the ankyrin repeat domain, and inhibition is alleviated by signaling via the C-terminal phosphorylation/ ubiquitin-ligase binding domain. J. Biol. Chem. 276, 26769-76. 

Jin, X., Touhey J. and Caudet, R. (2006). Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J. Biol. Chem. 281,25006-25010. 

Alternative substrates may exist for the PHDs proposed examples include RNA polymerase II and IkB kinase-P (which is negatively regulated by PHDl) (115, 116). However, unequivocal evidence (e.g., demonstration of hydroxylation by mass spectrometry) has not yet been demonstrated for these proteins. In contrast, FIH has been shown to catalyze hydroxylation of ankyrin repeat domain (ARD) proteins from the NFkB (nuclear factor kB) and Notch family at highly conserved as-paraginyl residues (117, 118). The ARD is a common protein motif, with over 200 human members of the ARD protein family being predicted. Evidence that ARD hydroxylation occurs frequently in human cells supports the assertion (117, 118) that posttranslational hydroxylation of cytoplasmic proteins in... 

DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. As- 137. paraginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J. Biol. Chem. 2007 282 24027-24038. 

AnkCap Ankyrin repeat domain C-terminal tail of PPip 1... 

Velyvis A, Yang Y, Wu C et al (2001) Solution structure of the focal adhesion adaptor PINCH LIMl domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. J Biol Chem 276 4932-4939... 

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