Nizatidine Paracetamol

Clmetldlne, nizatidine, and ranitidine do not appear to alter the pharmacokinetics of paracetamol to a clinically relevant extent... 

Nizatidine 300 mg given to 5 healthy subjects with paracetamol 1 g modestly increased the paracetamol AUC in the first 3 hours by 25%. Over this time period, there was also a nonsignificant 4% reduction in formation of paracetamol glucuronide, but this did reach statistical significance at 30 and 45 minutes. Nizatidine 150 mg had a similar, but smaller, effect. ... 

Any changes in the pharmacokinetics of paracetamol with these H2-recep-tor antagonists appear to be clinically unimportant. Thus, no special precaution would seem to be necessary when paracetamol is used with cimetidine, nizatidine or ranitidine. The effect of cimetidine on the oxidative metabolism of paracetamol has been investigated as a means of reducing paracetamol hepatotoxicity. However, it appears that cimetidine is not effective for this purpose. ... 

Itoh H, Nagano T, Takeyama M. Effect of nizatidine on paracetamol and its metabolites in human plasma. JEha/TwP anwaco/(2002) 54, 869-73. 

---