Nizatidine Alcohol

Drugs that may affect aspirin include activated charcoal, ammonium chloride, ascorbic acid or methionine, antacids and urinary alkalinizers, carbonic anhydrase inhibitors, corticosteroids, and nizatidine. Drugs that may be affected by aspirin include alcohol, ACE inhibitors, anticoagulants (oral), beta-adrenergic blockers, heparin, loop diuretics, methotrexate, nitroglycerin, NSAIDs, probenecid and sulfinpyrazone, spironolactone, sulfonylureas and exogenous insulin, and valproic acid. 

Avoid alcohol, aspirin, and smoking during nizatidine therapy... 

A meta-analysis of 24 studies showed that cimetidine and ranitidine, but not famotidine or nizatidine, caused small increases in blood alcohol concentrations (19). The mechanism is unclear, but one possibility is inhibition of gastric alcohol dehydrogenase. However, relative to accepted legal definitions of intoxication the effect of any histamine receptor antagonist on blood alcohol concentrations is unlikely to be clinically significant. 

Nizatidine. Ni/atidine. (V- 2- 2-((dimethylantino) methyl l-4-thiazolyl Intethyllthio )ethyl -/ -ntcthyl-2-nitro-l.l-cthenediamine (Axid). is an off-white to buff crystalline solid that is. soluble in water, alcohol, and chloroform. The pK s of the drug in water are 2.1 (side chain) and 6.8 (di-methylamino). 

B. Cimetidine, ranitidine, and nizatidine inhibit gastric mucosal alcohol dehydrogenase and therefore increase the systemic absorption of ethyl alcohol. 

Dimethylaminothioacetamide (200) and ethyl bromopyruvate (201) condensed to give the thiazole (202) which was reduced with lithium triethylborohydride to the alcohol (203). This condensed with 2-ami-noethane thiol in 48% hydrobromic acid to the aminosulphide (204) which with the amine (198) gave nizatidine (205) Scheme 5.47.) [258, 259]. 

A study in subjects given 0.75 g/kg of alcohol found that single doses of cimetidine 800 mg, nizatidine 300 mg, or ranitidine 300 mg raised blood alcohol levels at 45 minutes by 26% (from 75.5 to 95.2 mg%), 17.5% (from 75.5 to 88.7 mg%) and 3.3% (75.5 to 78 mg%), respectively, and the AUCs at 120 minutes were increased by 25%, 20% and 9.8%, respectively. Each of the subjects said they felt more inebriated after taking cimetidine or nizatidine. Another report briefly mentions that both nizatidine and ranitidine have similar effects on alcohol absorption to cime-tidine. ... 

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