Nizatidine NSAIDs

Drugs that may affect aspirin include activated charcoal, ammonium chloride, ascorbic acid or methionine, antacids and urinary alkalinizers, carbonic anhydrase inhibitors, corticosteroids, and nizatidine. Drugs that may be affected by aspirin include alcohol, ACE inhibitors, anticoagulants (oral), beta-adrenergic blockers, heparin, loop diuretics, methotrexate, nitroglycerin, NSAIDs, probenecid and sulfinpyrazone, spironolactone, sulfonylureas and exogenous insulin, and valproic acid. 

Most of these interactions between the NSAIDs and cimetidine, famotidine, nizatidine or ranitidine appear to be of no particular clinical importance. The general relevance of the isolated case of increased lomoxicam levels and severe gastric irritation with ranitidine is uncertain, but probably small. The H2-receptor antagonists as a group may protect the gastric mucosa from the irritant effects of the NSAIDs and concurrent use may therefore be advantageous. 

---