Nitric oxide metabolism

Nagata K, H Yu, M Nishikawa, M Kashiba, A Nakamura, EE Sato, T Tamura, M Inoue (1998) Helicobacter pylori generates superoxide radicals and modulates nitric oxide metabolism. J Biol Chem 273 14071-14073. 

Bloom IT, Bentley FR, Spain DA, Garrison RN An experimental study of altered nitric oxide metabolism as a mechanism of cyclosporin-induced renal vasoconstriction. Br.J.Surg. 82 195-198,1995... 

Cancers with a high frequency of CpG transitions include colorectal cancer (45%), adenocarcinoma of the esophagus (48%) and stomach (34%), tumors of the brain (35%) and uterus (35%), and some hematopoietic malignancies (e.g., Burkitt s lymphoma (32%) (Fig. 3B). In colorectal carcinogenesis, p53 mutation is typically a relatively late event that correlates with the acquisition of an invasive potential (Fearon and Vogelstein, 1990). Acquisition of a CpG mutation in this context may be a consequence of deregulated cell proliferation, DNA instability, or altered nitric oxide metabolism. In the development of adenocarcinoma of the esophagus, however, mutations are often detectable in the preneoplastic lesion, Barrett s mucosa (Montesano et al., 1996). In the latter case, it has been speculated that... 

As for the biochemistry involved, it has been proposed that the L-arginine to nitric oxide metabolic pathway is activated, whereby the greater amount of nittic oxide produced is cytotoxic to cancer cells. Not only this, bnt the nitric oxide produces a greater vascular blood flow, and the enzyme streptokinase naturally present in the toxins may lyse or destroy blood clots. Another beneficial effect was apparently against osteoarthritis. 

Overall, these regulatory effects of EGb 761 on nitric oxide metabolism, NF-kB activity, and chemokine expression suggest that these may be implicated in the beneficial effects of Ginkgo biloba on inflammatory disorders and atherogenesis. 

Turpeinen, A.M., Basu, S., and Mutanen, M., A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. Lipids, 34 (Suppl. 1), 291S-292S, 1999. 

Link Between Catecholamine and Nitric Oxide Metabolism... 

Vaziri, N.D., Ding, Y., Ni, Z., Gonick, H.C., 1997. Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension effect of lazaroid therapy. Kidney Int. 52, 1042—1046. 

Numerous flavonoids have been reported to affect cellular signaling processes, from kinases to transcription factors. In fact, oligomeric procyanidins from pine bark were found to prevent the activation of the proinflammatory transcription factor NF-k-B on ultraviolet (UV) exposure [3]. The same procyanidins are also potent modulators of nitric oxide metabolism [4,5]. 

In contrast, many relatively short intervention trials with either supplements or foods have provided supporting evidence for the benefits of flavonoids for vascular health. The majority of these studies are of an acute nature in which relatively high doses are provided and various biomarkers, including, for example, platelet aggregation [20], flow mediated arterial dilation and nitric oxide metabolism [21], and plasma LDL cholesterol [22] are quantified over the following hours or days. Some studies... 

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