Nitric oxide delivery systems

Young, J. D. (1994). A universal nitric oxide delivery system. Br. J. Anaesth. 73, 700-702. 

Polypyridine nithenium complexes are widely studied as nitric oxide delivery systems [6]. They are useful as artificial light-harvesting systems for technological purposes and as chemiluminescence probes. C(s-[Ru(bpy)(NO)Cl] and [Ru(tby)(NO)(bpy)] complexes, shown in F res 14 and 15, constitute a representative class of these compounds capable of functioning as drug carriers. 

Pulmonary hypertension is a devastating, potentially fatal disorder. Recent years have witnessed a great expansion in our understanding of the molecular pathophysiology of this condition. Options for therapy have just become available in recent years, focused either on the prostacyclin pathway or the nitric oxide pathway for pulmonary arteriolar relaxation. Continuous infusion of prostacyclin has been successful, demonstrating the relevance of the former pathway. The efficacy of both inhaled nitric oxide and systemic sildenafil support the latter. In the future, gene transfer could be used for sustained delivery of either of these agents, by means of... 

Kavdia, M. and Lewis, R.S. (2003). Nitric oxide delivery in stagnant systems via nitric oxide donors a mathematical model. Chem. Res. Toxicol. 16, 7-14. 

There are experiences of ambulatory treatment of patients with pulmonary hypertension, with inhaled nitric oxide and with prostaglandins, in both cases using an ambulatory delivery system. In our center we have an outpatient treatment program of pulmonary hypertension with inhaled iloprost leading in some patients to significant improvement in pulmonary hypertension and in the quality of life with no adverse effects. 

The exact method of delivery and monitoring of inhaled nitric oxide therapy varies with the clinical indication and duration of treatment. " A number of descriptions have appeared, including the Douglas bag, the titration of nitric oxide continuously into the inspiratory limb of the ventilator circuit, and the use of a ventilator nebulizer to deliver nitric oxide during inspiration only or double-blender techniques adaptable to a variety of circumstances. We reviewed our initial experience with delivery and monitoring techniques in a variety of clinical settings in 123 patients and subsequently adapted a system to simplify the delivery in continuous-flow circuits suitable for paralyzed infants, as many others have done before us. ... 

Watkins, D. N., Jenkins, I. R., Rankin, J. M and Clarke, G. M. (1993). Inhaled nitric oxide in severe acute respiratory failure—Its use in intensive care and description of a delivery system. Anaesth Intens. Care. 21, 861-875. 

Surface graft polymerization of poly(ethylene glycol) acrylate was used to modify the surface of PDMS. Templates with channels were formed from this material and sol-gel chemistry was used to form amino-silane doped xerogel microarrays. These structures were then used to release nitric oxide at various rates, by control of micropattern dimensions, type and concentration of the amino-silane, and so on. This method parallels the use of polymers in controlled drug-delivery systems. ... 

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