Nitric oxide, cyclic GMP signaling

Huzoor-Akbar Role of nitric oxide/cyclic GMP signaling mechanisms in increased platelet sensitivity... 

Nitric Oxide-Cyclic GMP Signaling System N-TERMINUS cGMP A cGMP B CATALYTIC... 

Murad, F., Forstermann, U., Nakane, M., Pollock, J., Tracey, R., Matsumoto, T., and Buechler, W. (1993). The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication. Adv. Second Messenger Phosphoprotein Res. 28,101-109. 

Southam, E. and Garthwaite, J. (1993) The nitric oxide-cyclic GMP signalling pathway in rat brain. Neuropharmacology 32,1267-1277... 

Murad, F. (1994). Regulation of cytosolic guanylyl cyclase by nitric oxide The NO-cyclic GMP signal transduction system. Adv. Pharmacol. 26, 19-33. 

Regulation of Cytosolic Guanylyl Cyclase by Nitric Oxide The NO-Cyclic GMP Signal Transduction System Ferid Murad... 

Fig. 1. Nitric oxide (NO) synthesis by nitric oxide synthase (NOS) (upper left), NO reaction with soluble guanylate cyclase (sGC) (middle), and formation of cyclic GMP, which causes tissue-specific signaling (right). The roles of the salivary nitrophorins from Rhodnius prolixus in storing and releasing NO and binding histamine are included (lower left).

Mittal, C. K. (1995). Oxygen-radicals/nitric oxide mediate calcium-dependent action of hormones on cyclic GMP system A novel concept in signal transduction. Mot. Cell. Biochem. in press. 

Murad, F. Shattuck lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. New Engl J. Med. 2006, 555(19), 2003-2011. 

Ignarro LJ (1990) Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide a unique transduction mechanism fra- transcellular signaling. Pharmacol Toxicol 67 1-7... 

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