Nitrendipine

In addition to the vascular effects, calcium channel blockers (Table 6) such as isradipine, nifedipine (Table 3), and nitrendipine, produce natriuretic... [Pg.141]

Many dihydropyridines that are of therapeutic interest are unsymmetrically substituted at C-3 and C-5. The synthesis of such compounds is possible from separately prepared Knoevenagel condensation products 6, as is outlined in the following scheme for nitrendipine 8, which is used in the medical treatment of high blood pressure." ... [Pg.153]

Widely used DHPs are nifedipine, amlodipine, nitrendipine, nisoldipine, nicardipine, and isradipine. They directly bind to and stabilize the inactivated state of the... [Pg.296]

Fast DHP-induced lowering of blood pressure results in compensatory sympathetic activation and a subsequent increase in heart rate and cardiac oxygen demand. This unfavorable effect has been mainly associated with the use of short-acting DHPs, such as nonretarded formulations of nifedipine, nitrendipine, or... [Pg.298]

The IC50 values for the inhibition of [3H]-nitrendipine binding for the metabolite has a value of 203 nM in comparison to SR 33557 which reaches a value of only 0.6 nM. [Pg.159]

QHiqO 141-97-9) see Aminophenazone Baclofen Cefotaxime Ceftazidime Chloroquine Cloricromen Cloxacillin Dipyridamole Felodipine Flutoprazepam Hymecromone Kawain Lacidipine Leflunomide Methylthiouracil Nevirapine Nitrendipine Oxacillin Pentoxifylline Propyphenazone Sulfamerazine acetoacetic acid 4-(trifluoromethyl)anilide (C H (,F3N02 351-87-1) see Leflunomide acetoacetyl chloride... [Pg.2280]

QH15NO2 5006-62-2) see Tiagabine a-ethyl-4-nitrobenzeneacetic acid (C (,H, N04 7463-53-8) see Indobufen ethyl 4-nitrobenzoate (C9H9NO4 99-77-4) see Benzocaine ethyl 3-nitro-benzylideneacetoacetate (CijHijNO, 39562-16-8) see Nitrendipine ethyl At-(2-nitro-6-chlorobenzyl)glycinate... [Pg.2383]

CjHjO., 105-45-3) see Ampicillin Cefradine Cerivastatin sodium Dicloxacillin Epicillin Felodipine Flucloxacillin Fluvastatin sodium Nifedipine Nitrendipine Sultamicillin Talampicillin... [Pg.2411]

C5H(jN02 14205-39-1) see Amlodipine Aranidipine Barnidipine Benidipine Isradipine Lercanidipinc hydrochloride Manidipine Nicardipine Nisoldipine Nitrendipine... [Pg.2411]

C7H5NO3 99-61-6) see Bamidipine Benidipine Efonidipine hydrochloride ethanol lopanoic acid Lercanidipine hydrochloride Manidipine Nicardipine Nilvadipine Nimodipine Nitrendipine Rosoxacin nitrobenzene... [Pg.2425]

Anti-infective artemether, saguinavir Antilipemic atorrastatin, lovastatin, simvastatin Cardiovascular carvedilol, cilostazole, felodipine, nicardipine, nifedipine, nimodipine, nisoldipine, nitrendipine, verapamil... [Pg.65]

An additional example of a bioavailability-predicted absorption plot is shown for a series of calcium antagonists (Fig. 19.8). Again there is considerable scatter in the data, and the four compounds - felodipine, nisoldipine, diltiazem, and verapamil -are predicted to be much better absorbed than was actually observed. Some of these compounds are known to undergo rapid first-pass metabolic clearance, and are also P-gp inhibitors or substrates (diltiazem and felodipine are P-gp substrates nicardipine and nitrendipine are P-gp inhibitors [25] verapamil is a P-gp inhibitor), and this might contribute to the scatter obtained in the graph. [Pg.454]

Benetos A, Cambien F, Gautier S et al. Influence of the angiotensin-II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arteri-... [Pg.35]

Nitrendipine Verapamil Unchanged Procainamide Zidovudine Quinapril Repaglinide... [Pg.889]

Calcium channel blockers Nicardapine (i) Nimodipine (i) Nitrendipine (i)... [Pg.44]

Ehlert FJ, Roeske WR, Itoga E, Yamamura HI. (1982) The binding of [ H]-nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats. Life Sci 30 2191-2202. [Pg.220]

Nitrendipine and felodipine are used in the treatment of hypertension. Ni-modipine is given prophylactically after subarachnoidal hemorrhage to prevent vasospasms due to depolarization by excess K liberated from disintegrating erythrocytes or blockade of NO by free hemoglobin. [Pg.122]

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