Ranitidine Nitrendipine

Cimetidine 800 mg given before, and 400 mg in divided doses given after, a single 20-mg dose of nitrendipine was found to increase its bioavailability by 154% but the haemodynamic effects were unchanged. Another study found that ranitidine increased the AUC of oral nitrendipine 20 mg daily for 1 week by about 50% and decreased its clearance, but there were no changes in the haemodynamic measurements (systolic time intervals, impedance cardiography). A further study found that ranitidine increases the AUC of nitrendipine by 89%, but this does not appear to be clinically significant. ... 

Ranitidine does not interact significantly with diltiazem, nimodipine, nisoldipine or nifedipine, and is possibly a non-interacting alternative for cimetidine with other calcium-channel blockers. Note that the nitrendipine AUC was increased by 50% and 89% by ranitidine, although this was not considered clinically relevant. 

Kirch W, Nahoui R, Ohnhaus EE. Ranitidine/nitrendipine interacticn. CUn Pharmacol Ther... 

Halabi A, Nahoui R, Kirch W. Influence of ranitidine on kinetics of nitrendipine and on nai-invasive hemod3mamic parameters. Ther Drug Monit ( 99( ) 12, 303-4. 

Santos SR, Storpirtis S, Moreira-FiUio L, Donzella H, Kirch W. Ranitidine increases the bioavailability of nitrendipine in patients with arterial h3 ertension. Braz J Med Biol Res... 

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