Nitrendipine Digoxin

Kirch W, Logemann C, Heidemann H, Santos SR, Qhnhaus EE. Nitrendipine/digoxin interaction. J Cardiovasc Pharmacol 1987 10(Suppl 10) S74—5. 

Interactions of digoxin with nitrendipine (182) and bepridil (183) have also been described. 

Calcium channel blockers have varying effects on the disposition of digoxin. The calcium channel blockers for which varying amounts of information are available include cinnarizine, diltiazem, felodipine, fendiline, gallo-pamil, isradipine, lidoflazine, mibefradil, nicardipine, nifedipine, nitrendipine, tiapamil, and verapamil (238). 

Concurrent use can be valuable. Felodipine, gallopamil, lac-idipine, nicardipine and nisoldipine cause small but normally clinically unimportant increases in digoxin levels, while am-lodipine, isradipine and nimodipine appear not to interact. The situation with nitrendipine is uncertain but it possibly causes only a small rise in digoxin levels. 

Kirch W, LogemannC, HeidemannH, Santos SR, Ohnhaus EE. Effect of two different doses of nitrendipine on steady-state plasma digoxin levels and systolic time intervals. EurJ Clin... 

Ziegler R, Wingender W, Boehme K, Raemsch K, Kuhlmann J. Study of pharmacokinetic and pharmacodynamic interaction between nitrendipine and digoxin. J Car ovasc Pharmacol ( 9S7) 9 (Suppl 4), S101-S106. 

---