Nitrendipine NSAIDs

There is evidence that most NSAIDs can increase blood pressure in patients treated with antihypertensives, although some studies have not found the increase to be clinically relevant. In various small studies, indometacin appeared not to reduce the hypotensive effects of amlodipine, felodipine, nicardipine, nimodipine or verapamil, but it did in one of two studies with nifedipine, and one study with nitrendipine. Similarly, ibuprofen caused a small reduction in the antihypertensive effects of amlodipine. Diclofenac and sulindac appear not to interact with nifedipine, nor ibuprofen, naproxen, piroxicam or sulindac with verapamil, nor naproxen with nicardipine. Low-dose aspirin did not alter the antihypertensive effect of felodipine or nifedipine in one study, and long-term aspirin did not alter the cardiovascular benefits of nitrendipine in another. Diclofenac reduces verapamil serum levels and raises those of isradipine, but these changes are probably unimportant. 

Nitrendipine. A post-hoc analysis of the Syst-Eur trial of nitrendipine-based antihypertensive treatment found no difference in cardiovascular outcome between 861 patients who were also using long-term aspirin (700 patients) and/or other NSAIDs (161) and 2882 patients who had never taken aspirin or NSAIDs. Patients in this trial were randomised to receive nitrendipine, which could be combined or replaced by enalapril, hydrochlorothiazide, or both. ... 

NSAID non-steroidal anti-inflammatory drugs nitrendipine nucleophile PEGA polyethylene glycol... 

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