Nitrendipine Cimetidine

Soons PA, Vogels BA, Roosemalen MC, et al. Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans. Clin Pharmacol Ther 1991 50(4) 394-403. 

Cimetidine also increases plasma concentrations of nitrendipine and nisoldipine (182,193). 

Soons, P.A. Vogels, B.A. Roosemalen, M.C. Schoemaker, H.C. Uchida, E. Edgar, B. Lundahl, J. Cohen, A.F. Breimer, D.D. Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans. Clin. Pharmacol. Ther. 1991, 50, 394—403. 

Cimetidine 800 mg given before, and 400 mg in divided doses given after, a single 20-mg dose of nitrendipine was found to increase its bioavailability by 154% but the haemodynamic effects were unchanged. Another study found that ranitidine increased the AUC of oral nitrendipine 20 mg daily for 1 week by about 50% and decreased its clearance, but there were no changes in the haemodynamic measurements (systolic time intervals, impedance cardiography). A further study found that ranitidine increases the AUC of nitrendipine by 89%, but this does not appear to be clinically significant. ... 

Ranitidine does not interact significantly with diltiazem, nimodipine, nisoldipine or nifedipine, and is possibly a non-interacting alternative for cimetidine with other calcium-channel blockers. Note that the nitrendipine AUC was increased by 50% and 89% by ranitidine, although this was not considered clinically relevant. 

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