NIH roadmap

NIH Roadmap for Medical Research, http //nihroadmap.nih.gov/ (accessed October 1, 2005). 

Over the last 10 years there has been a major initiative to bring HTS into the academic community. The NIH roadmap has a mission to build a better toolbox for medical research in the twenty-first century and to empower the research community to use small molecule compounds in their research, whether as tools to perturb genes and pathways, as imaging probes in basic or clinical applications, or as starting points to the development of new therapeutics for human disease. 

Medicinal plant use http //www.siu.edu/ ebl/leaflets/juand9.htm NIH Roadmap Initiative http //nihroadmap.nih.gov/overview.asp... 

This work was supported by the Molecular Libraries Irutiative of the NIH Roadmap for Medical Research and the Intramural Research Program of the National Human Genome Research Institute, NIH. We thank Daryl Leja for the illustrations used in this work. 

It is only in the past 5 years or so that chemical probe development has really taken off. This has largely been driven by the NIH roadmap initiative which engaged a network (Molecnlar Libraries Probe Production Centers Network http //mli.nih.gov/mli/ mlpcn/mlpcn/) of academic-based centers that provided state-of-the-art high-throughput screening (HTS) capabilities of a large diverse small-molecule library (the Molecular Libraries Small Molecule Repository (MLSMR) >350,000 compounds) as well as much expertise in the activities of assay development and downstream hit to probe (http //mli.nih.gov/mli/). Prior to this initiative, HTS was almost exclusively conducted within pharmacentical... 

This work is supported by NIH Roadmap grant U54 HG005033 and Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute. 

In light of the benefits of more successful translational research to universities as well as patients, steps are being taken to address these difficulties. The recent NIH Roadmap for Medical Researcli includes grant funding meant to encourage the multidisciplinary training... 

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