Nicotinic acid tablets

Weak acid/strong base titration is used in the pharmacopoeial assays of benzoic acid, citric acid, chlorambucil injection, mustine injection, nicotinic acid tablets and undecanoic acid. 

Nicotinic Acid Tablets (200 mg) Nicotinamide see Vitamin B3 Nifedipine Tablet Cores (10 mg) Nitrendipine Tablets (25 mg) Nitrofurantoin Tablet Cores (100 mg) Nitrofurantoin Tablets (100 mg) Norephedrine Syrup (40 mg/10 g) Nystatin Suspension (100,000 i.u./ml) Nystatin Tabet Cores (200 mg) Nystatin Tablets (50 mg and 100 mg)... 

Oral 10, 20, 40 mg tablets extended release (Altoprev) 10, 20, 40, 60 mg Niacin, nicotinic acid, vitamin B3 (generic, others)... 

D.A. Shah, K.K. Bhatt, R.S. Mehta, M.B. Shankar, S.L. Baldania, RP-HPLC method for the determination of atorvastatin calcium and nicotinic acid in combined tablet dosage form, Indian J. Pharm. Sd. 69 (2007) 700-703. 

The vitamin niacin (nicotinic acid, C6H5N02) can be isolated from a variety of natural sources such as liver, yeast, milk, and whole grain. It also can be synthesized from commercially available materials. From a nutritional point of view, which source of nicotinic acid is best for use in a multivitamin tablet Why ... 

Lindberg, N.-O. Preparation of effervescent tablets containing nicotinic acid and sodium bicarbonate. Acta Pharm. Suec. 1970, 7, 23-28. 

Aluminum Nicoliiult. 3-Pyridinecarboxytic acid aluminum salt tris(nieotinato)aluminum nicotinic acid aluminum salt Alunitine Nicalex. CnH)tAlN]0( mol wt 393.30. C 54.97%. H 3.08%, Al 6.86%, N 10.68%, O 24.41%. Each tablet of 625 mg is a complex consisting of aluminum nicottnate. nicotinic acid and aluminum hydroxide equivalent in activity to 500 mg nicotinic acid. Manuf of suitable compositions Miale, U8. pat. 2,970,082 (196] to Walker Labs.). 

Beilstein Handbook Reference) Arecaidine Areoaine BRN 0112366 Methylguvacine N-Methylguvacine Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl- NSC 76017 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl- 1,2,6,6-Tetrahydro-1-methylnioo-tinic acid 1,2,5,6-Tetrahydro-1-methyl-3-pyridine-carboxylic acid. Isolated from betel nuts. Plates or tablets, mp = 232° (dec)insoluble in EtOH, Et20, CeHe, CHCI3, very soluble in H2O. 

Nicotinic acid is readily absorbed. Peripheral vasodilation is seen within 20 minutes, and peak plasma concentrations occur within 45 minutes. The half-life of the compound is approximately one hour, thus necessitating frequent dosing or an extended-release formulation. Extended release tablets produce peripheral vasodilation within 1 hour, reach peak plasma concentrations within 4 to 5 hours, and have a duration of 8 to 10 hours. 

Dosing of nicotinic acid should be titrated to minimize adverse effects. An initial dose of 50 to 100 mg t.i.d. often is used with immediate-release tablets. The dose then is gradually increased by 50 to 100 mg every 3 to 14 days, up to a maximum of 6 g/day, as tolerated. Therapeutic monitoring to assess efficacy and prevent toxicity is essential until a stable and effective dose is reached. Similar dosing escalations are available for extended-release products, with doses normally starting at 500 mg once daily at bedtime. (7,15,21). 

Sampathkumar et al. 2006 Single treatment of 34 extended release nicotinic acid (375 mg) tablet in patients on haemodialysis for a mean period of eight months. This was associated with a significant decrease in both plasma phosphate and calcium phosphate product. Restrepo et al. 2008 In nine patients with CKD and on dialysis treated with 1000 mg nictonic acid for eight months decreased LDL-c, triglyceride and increased HDL-c. The authors recommended that nicotinic acid is efficient, very well tolerated and economical in comparison with other drugs, which makes it ideal for the treatment of patients with hyperlipidaemia and refractory hyperphosphatemia to classical treatments. 

Svedmyr, N., and Harthon, L., 1970. Comparison between the absorption of nicotinic acid and pentaerythritol tetranicotinate (Perydt) from ordinary and enterocoated tablets. Acta Pharmacologica et Toxicologica. 28 66-74. 

Consider, for example, how you could answer the following questions What is the hydronium-ion concentration of 0.10 M niacin (nicotinic acid) What is the hydronium-ion concentration of the solution obtained by dissolving one 5.00-grain tablet of aspirin (acetylsalicylic acid) in 0.500 L of water If these were solutions of strong acids, the calculations would be simple 0.10 M monoprotic acid would yield 0.10 M HsO ion. However, because niacin is a weak monoprotic acid, the HsO concentration is less than 0.10 M. To find the concentration, you need the equilibrium constant for the reaction involved, and you need to solve an equilibrium problem. 

Tablets of Nicotinic Acid, B,P, Usually contain 50 mg of nicotinic acid.

Although the B.P. directs that the nicotinic acid should be extracted with hot neutral ethanol and the extract diluted with water and titrated, this procedure is not necessary for tablets with normal excipients and a direct titration on the powdered tablets with 0-lN alkali to phenol red is satisfactory. 1 ml O IN 0 01231 g CgH OgN. 

Dried Yeast, B.P.C., and Tablets of Yeast, B.P.C, (containing 5 grains of dried yeast), are assayed for nicotinic acid by the microbiological method given above. 

Thomas, B.R. Fang, X.G. Shen, R Ghodbane, S. Mixed ion pair liquid chromatography method for the simultaneous assay of ascorbic acid, caffeine, chlorpheniramine maleate, dextromethorphan HBr monohydrate and paracetamol in Frenadol sachets. J.Pharm.Biomed.Anal., 1994,12, 85-90 [simultaneous caffeine, chlorpheniramine, dextromethorphan, vitamin C formulations] van der Veen, J. Eissens, A.C. Lerk, C.F. Controlled release of paracetamol from amylodextrin tablets In vitro and in vivo results. Pharm.Res., 1994, 11, 384-387 [plasma pharmacokinetics] Abounassif, M.A. Abdel-Moety, E.M. Gad-Kariem, R.A. HPLC-quantification of diethylamine saliqylate and methyl nicotinate in ointments. J.Liq.Chromatogn, 1992,15, 625-636 [formulations ointments simultabeous diethylamine salicylate, methyl nicotinate acetaminophen is IS simultaneous methyl paraben, propyl paraben... 

---