Diethylamine salicylate

Accidental subcutaneous administration of oxaliplatin resulted in a red-brown painful swelling and sclerosis of the skin within 8 days (232). The symptoms were worst 1 week after extravasation and lasted for about 5 weeks, but the patient, a 52-year-old woman, recovered fully. Acute intervention included local fluid instillation to dilute the extravasation, removal of the cannula, cold packs, and a gel containing aescin and diethylamine salicylate. 

Set Becomix to 50°C and transfer diethylamine salicylate solution to the cream at 50°C while stirring. 

Thomas, B.R. Fang, X.G. Shen, R Ghodbane, S. Mixed ion pair liquid chromatography method for the simultaneous assay of ascorbic acid, caffeine, chlorpheniramine maleate, dextromethorphan HBr monohydrate and paracetamol in Frenadol sachets. J.Pharm.Biomed.Anal., 1994,12, 85-90 [simultaneous caffeine, chlorpheniramine, dextromethorphan, vitamin C formulations] van der Veen, J. Eissens, A.C. Lerk, C.F. Controlled release of paracetamol from amylodextrin tablets In vitro and in vivo results. Pharm.Res., 1994, 11, 384-387 [plasma pharmacokinetics] Abounassif, M.A. Abdel-Moety, E.M. Gad-Kariem, R.A. HPLC-quantification of diethylamine saliqylate and methyl nicotinate in ointments. J.Liq.Chromatogn, 1992,15, 625-636 [formulations ointments simultabeous diethylamine salicylate, methyl nicotinate acetaminophen is IS simultaneous methyl paraben, propyl paraben... 

Fig. 4.3. Potentiometric titration of phenol and salicylic acid. Solvent pyridine-dimethylfuran-diethylamine (4 7 9, v/v) titrant (C4H9)3CH3NOH, 0.1 Nin IPA glass-calomel electrode (aq.).

DE Patent 39334273, B 65 D 65/38, C 08 K 5/17. Anti-corrosion packaging material for metals - comprising combination of thermoplastic polymer and active mixture of salicylic acid-octadecyl amine salt and benzoic acid-diethylamine salt. J. Bouzek and P Bouzek, 1991. 

Spasmolytol, as its name suggests, is an antispasmodic. Given this retrosynthetic analysis, propose a synthesis for spasmolytol from salicylic acid, ethylene oxide, and diethylamine. 

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