Nicotinic acid Aluminum nicotinate

Synonym Neatsfoot Oil Necatorina Nechexane Neutral Ahhonium Pluoride Neutral Anhydrous Calcium Hypochlorite Neutral Lead Acetate Neutral Nicotine Sulfate Neutral Potassium Chromate Neutral Sodium Chromatetanhydrous Neutral Verdigris Nickel Acetate Nickel Acetate Tetrahyorate Nickel Ammonium Sulfate Nickel Ammonium Sulfate Hexahydrate Nickel Bromide Nickel Bromide Trihydrate Nickel Carbonyl Nickel Chloride Nickel Chloride Nickel Cyanide Nickel Iiu Fluoborate Nickel Fluoroborate Solution Nickel Fluoroborate Nickel Formate Nickel Formate Dihyorate Nickel Nitrate Nickel Nitrate Hexahydrate Nickel Sulfate Nickel Tetracarbokyl Nickelous Acetate Nickelous Sulfate Nicotine Nicotine Sulfate Nifos Nitralin Nitram O-Nitraniline P-Nitraniline Nitric Acid Nitric Acid, Aluminum Salt Nitric Acid, Iron (111) Salt Compound Name Oil Neatsfoot Carbon Tetrachloride Neohexane Ammonium Fluoride Calcium Hypochlorite Lead Acetate Nicotine Sulfate Potassium Chromate Sodium Chromate Copper Acetate Nickel Acetate Nickel Acetate Nickel Ammonium Sulfate Nickel Ammonium Sulfate Nickel Bromide Nickel Bromide Nickel Carbonyl Nickel Chloride Nickel Chloride Nickel Cyanide Nickel Fluoroborate Nickel Fluoroborate Nickel Fluoroborate Nickel Formate Nickel Formate Nickel Nitrate Nickel Nitrate Nickel Sulfate Nickel Carbonyl Nickel Acetate Nickel Sulfate Nicotine Nicotine Sulfate Tetraethyl Pyrophosphate Nitralin Ammonium Nitrate 2-Nitroaniline 4-Nitroaniline Nitric Acid Aluminum Nitrate Ferric Nitrate... 

SYNS ALUNITINE MICALEX NICOTINIC ACID, ALUMINUM SALT 3-PYRIDINECARBOXYLIC ACID, ALUMINUM SALT TRIS(NTCTINATO)ALUMINUM... 

Aluminum Nicoliiult. 3-Pyridinecarboxytic acid aluminum salt tris(nieotinato)aluminum nicotinic acid aluminum salt Alunitine Nicalex. CnH)tAlN]0( mol wt 393.30. C 54.97%. H 3.08%, Al 6.86%, N 10.68%, O 24.41%. Each tablet of 625 mg is a complex consisting of aluminum nicottnate. nicotinic acid and aluminum hydroxide equivalent in activity to 500 mg nicotinic acid. Manuf of suitable compositions Miale, U8. pat. 2,970,082 (196] to Walker Labs.). 

Synonyms Nicotinic acid aluminum salt 3-Pyridinecarboxylic acid aluminum salt Tris (nicotinato) aluminum Empirical C18H12AIN3O6 Properties Solid m.w. 393.30 Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of NOx Uses Nutrient, dietary supplement, niacin source in foods for special dietary use Regulatory FDA 21CFR 172.310 Aluminum nitrate... 

Nicotinic acid aluminum salt. See Aluminum nicotinate... 

Aluminum nicotinate is prepared by dissolving nicotinic acid in hot water and adding a slurry of aluminum hydroxide to it. A slight excess of aluminum hydroxide is used in order that the final product would be free of nicotinic acid. The precipitate is collected on a filter and dried. The final product contains a mixture of aluminum nicotinate and a small but acceptable amount of aluminum hydroxide. 

Hydroxylamine hydrochloride Lithium aluminum hydride Nicotinic acid chloride... 

C iH5N02 59-67-6) see Aluminum nicotinate Inositol nicotinate Micinicate Nicorandil Nicotinamide Nicotinic acid benzyl ester Nikethamide Xantinol nicotinate nicotinonitrile... 

In a 2-1. three-necked flask, fitted with a sealed mechanical stirrer (Note 1), a reflux condenser protected with a calcium chloride tube, and a dropping funnel, is placed 123 g. (1 mole) of nicotinic acid (Note 2). The stirrer is started, and 500 ml. (818 g., 6.9 moles) of distilled thionyl chloride is added in a slow stream over a period of 15-20 minutes (Note 3). After the addition is complete, the mixture is heated on the steam bath with continuous stirring for 1 hour then the reflux condenser is replaced by one set for downward distillation, and the excess thionyl chloride is removed by distillation at reduced pressure as heating on the steam bath is continued (Notes 1 and 3). After most of the thionyl chloride has been distilled, 200 ml. of anhydrous benzene is added, and the benzene is distilled at reduced pressure. An additional 500 ml. of anhydrous benzene is added, then the flask is fitted with a thermometer and a reflux condenser and is placed in an ice-salt bath. The stirrer is started, and 330 g. (2.5 moles) of anhydrous aluminum chloride is added in portions over a period of 1 hour as the internal temperature is held between 5° and 10°. The ice bath is removed, and the flask is permitted to warm to room temperature and is finally healed under reflux for 6 hours. 

Hydroxylamine hydrochloride Nicotinic acid chloride Lithium aluminum hydride... 

Derivatives of pyridine-3,5-dicarboxylic acid have been shown to undergo reaction with lithium aluminum hydride by attack on the pyridine ring to form 1,4-dihydropyridines.57,58 Presumably the decrease in electron-density at the ring carbon atoms due to these substituents causes the ring to be extremely susceptible to hydride attack. Similar results were obtained with 3,5-dicyanopyridine derivatives. Methyl nicotinate, however, underwent reaction with LAH with exclusive reduction of the ester function.57 Recently the 3,5-dicyanopyridines have been reported to give mixtures of 1,2- and 1,4-dihydropyridines on reduction with LAH or sodium boro-hydride.20 ... 

The natural product was synthesized together with its 8-hydroxy isomer (160) via the cyclization of 4-methyl-2-(3-hydroxyphenyl) nicotinic acid (90). A11 four ring C monohydroxylated onychines have been prepared by a different, unambiguous route and their mass, UV, and H-NMR spectra discussed in detail, showing that the base- and aluminum chloride-induced bathochromic shifts are useful criteria for the location of phenol functions on the benzene ring of aza-fluorenones (97). 

Niacin (nicotinic acid) may be administered as aluminum nicotinate (Nicalex). This is acomplex of aluminum hydroxy nicotinate and niacin. The aluminum salt is hydrolyzed to aluminum hydroxide and niacin in the stomach. The aluminum salt seems to have no advantage nver the free acid. Hepatic reaction appears more prevalent than with niacin. 

Helv. Chim. Acta 24- supplemental issue in honor of Gadient Engi, p 26E (1941) by lithium aluminum hydride reduction of ethyl nicotinate Rosenmund- Zymalkowski, Ber, 85, 156 0952) Cohen, U.S, pat, 2,520.037 (1950) Mosher- Tessieri-J. Am. Chem, Soc, 73t 4926 (1951) of methyl nicotinate Bohlmann, Ber. 86, 1423 (1953). From 3 -cyanopyridine Chase, U.S. pat. 2,615,896 (1952 to Hoffmann-La Roche) from 3-aminomethylpyridine Schlapfer. U.S- pat, 2,547,048 (1951 to Hoffmann-La Roche) frnm thionicotinic acid S-methyl ester- Ruzicka, Prelog. UJS. pet. 2,509,171 (1950 to Ciba). 

Cyanopyridines are prepared by passage of nicotinic or isonicotinic acid, their ammonium salts, or amides over a dehydration catalyst at 350° in the presence of ammonia. Boron phosphate and aluminum phosphate are mentioned specifically as catalysts. ... 

In pharmaceutical preparations, nicotinic acid can be separated from nicotinamide by TLC on silica gel, aluminum oxide, and ion-exchange resins detection of the spots can be made by examination of the plates under UV light or by specific detection reagents. For a table listing the values of water-soluble vitamins, consult Hengen and deVries (1985). Nicotinic acid can be separated from nicotinamide and other water-soluble vitamins by TLC on silica gel using the mobile phase acetic acid-acetone-methanol-benzene (5 5 20 70). Expected Rp values of water-soluble vitamins in this system are as follows B2, 0.3 nicotinic acid, 0.75 nicotinamide, 0.55 65, 0.13 C, 0.27 (Hengen and deVries. 1985). 

Phenolic acids of E. arvense include di- -caffeoyl-me50-tartaric acid methy esters of protocatechuic and caffeic acids aconitic, oxalic, malic, tannic, arahinoic, and threonic acids minerals, including silicic acid and silicates (5-8%) water soluble up to 80%, potassium, aluminum, and manganese sterols, including campesterol isocuosterol, and brassinosteroids and others. Trace amounts of nicotine have been found in E. arvense ... 

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