Nicotinic acetylcholine receptors genes

Deneris ES, Boulter J, SwansonLW, Patrick , Heinemann S (1989) P3 A new member of nicotinic acetylcholine receptor gene family is expressed in brain, J Biol Chem 264 6268-6272 Drisdel RC, Green WN (2000) Neuronal a-bungarotoxin receptors are a7 homomers, J Neurosci 20 133-139... 

Wada E, McKinnon D, Heinemann S, Patrick J, Swanson LW (1990) The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (ct5) in the rat central nervous system. Brain Res., 526, 45-53. 

Feng, Y., Niu, T., Xing, H. et al. A common haplotype of the nicotine acetylcholine receptor a4 subunit gene is associated with vulnerability to nicotine addiction in men. Am. J. Hum. Genet. 75 112, 2004. 

Ajuh, P.M., Cowell, P., Davey, M.J. and Shevde, S. (1994) Cloning of a cDNA encoding a putative nicotinic acetylcholine receptor subunit of the human filarial parasite Onchocerca volvulus. Gene 144, 127-129. 

Fleming, J.T., Squire, M.D., Barnes, T.M., Tornoe, C., Matsuda, K., Ahnn,J., Fire, A., Sulston, J.E., Barnard, E.A., Sattelle, D.B. and Lewis, J.A. (1997) Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor svlbxmixs,. Journal of Neuroscience 17, 5843-5857. 

Wiley, L.J., Weiss, A.S., Sangster, N.C. and Li, Q. (1996) Cloning and sequence analysis of the candidate nicotinic acetylcholine receptor alpha subunit gene tar-1 from Trichostrongylus colubriformis. Gene 182,97—100. 

Leonard, S., Gault, J., Hopkins, J. et al. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch. Gen. Psychiatry 59 1085-1096,2002. 

Hiemke, C. et al., Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes, Neurosci. Lett., 214,171, 1996. 

Gotti C, Moretti M, Clementi F, Riganti L, McIntosh JM, Collins AC (2005) Expression of ni-grostriatal alpha 6-containing nicotinic acetylchohne receptors is selectively reduced, but not eliminated, by beta 3 subunit gene deletion. Mol Pharmacol 67 2007-2015 Gotti C, Zoli M, Clementi F (2006a) Brain nicotinic acetylcholine receptors native subtypes and their relevance. TIPS 27 482 91... 

Marks MJ, Meinerz NM, Drago J, Collins AC (2007) Gene targeting demonstrates that a4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [ H]epibatidine binding sites and components of biphasic Rb+ efflux with high and low sensitivity to stimulation by acetylcholine. Neuropharmacol 53 390-405... 

There is considerable diversity among nicotinic acetylcholine receptors, and at least one source of this diversity is the multiplicity of acetylcholine receptor genes. Cholinergic-nicotinic receptors in skeletal muscle are different from those in autonomic ganglia and the central nervous system. 

Bentley, G.N., Jones, A.K., Oliveros Parra, W.G. and Agnew, A. (2004) ShAR1 alpha and ShAR1 beta novel putative nicotinic acetylcholine receptor subunits from the platyhelminth blood fluke Schistosoma. Gene 329, 27-38. 

Abstract The existence of neuronal nicotinic acetylcholine receptor (nAChRs) expression in the brain was discovered 30 years ago. Although the relevance of neuronal nAChRs at the time of their discovery was debated, it is now clear that nAChRs are expressed throughout the brain where they mainly serve a modulatory role. Neuronal nAChRs increasingly have become of interest due to the many observations that various nAChR subtypes exhibit abnormal expression or function in a wide assortment of neurological diseases. In this review, the putative role of nAChRs in brain disease is discussed in several broad categories (1) diseases associated with a loss of nAChRs, (2) diseases associated with innate differences in the expression of nAChRs, (3) diseases associated with genetic variability in genes that code for nAChR subunit proteins, and (4) diseases in which nAChRs are implicated based on the observation that nicotine has a therapeutic effect. 

Stitzel JA (2008) Naturally occurring genetic variability in the nicotinic acetylcholine receptor alpha4 and alpha7 subunit genes and phenotypic diversity in humans and mice. Front Biosci 13 477 91... 

Clustering of novel with known genes [8]. The ESTs (expressed sequence tags), SC6 and SC7 cluster with neurotransmitter-related genes. Upper right panel SC6 has a temporal expression pattern similar to that of nAChRd (nicotinic acetylcholine receptor delta subunit). Lower left panel ... 

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