Nicotine Polacrilex

Nicotine polacrilex (gum)0 First-line Initial dose depends on smoking history 2-4 mgevety 1-8 hours 12 weeks (taper down over time) Heart rate and blood pressure should be monitored periodically during nicotine replacement therapy. Al... 

Choi JH, Dresler CM, Norton MR, Strahs KR (2003) Pharmacokinetics of a nicotine polacrilex lozenge. Nicotine Tob Res 5(5) 635-644... 

Smoking cessation aids Nicotine polacrilex gum dosage varies consult product labeling Nicorette, various generic Nicotine replacement products in combination with behavioral support approximately double long-term cessation rates compared with placebo. Review directions for use carefully, since product strengths vary and self-titration and tapering may be necessary. 

Nicotine polacrilex lozenge, dosage varies consult product labeling Commit, various generic ... 

Sherwood et al.75 administered nicotine polacrilex gum (0 and 2 mg) three times at 1-h intervals to smokers who were overnight deprived and measured CFF after each administration. CFF threshold was increased over predose baseline after the first 2-mg dose, but no further increase after the second and third doses was observed. Thus, the initial dose appeared to reverse a deprivation-induced deficit, and subsequent doses maintained normal functioning. Baseline CFF was not measured before subjects were tobacco abstinent. No effect of nicotine on CFF was reported following administration of nicotine polacrilex or subcutaneous (SC) nicotine injections to 24-h abstinent smokers, nonabstinent smokers, and nonsmokers.76-79 The lack of effect of nicotine in the absence of nicotine deprivation is consistent with the data of Sherwood et al.,75 further suggesting that nicotine reverses withdrawal-induced deficits, but does not produce true enhancement of CFF threshold. 

Numerous studies investigating focused attention have used reaction time tests. Nicotine polacrilex gum (2 mg) produced faster motor reaction time, but did not affect recognition reaction time in overnight deprived smokers,75 nonabstinent smokers,76 and a group of nonabstinent smokers and nonsmokers.78 Le Houezec et al.84 found that SC nicotine (0.8 mg) increased the number of fast... 

In contrast to these positive effects of nicotine on memory, three studies86 93 110 reported no effect of nicotine on tests of immediate and delayed recall in nicotine-deprived smokers, and Houston et al.111 reported that immediate and delayed recall was impaired after smoking a nicotine cigarette compared to a nicotine-free cigarette. In studies of nondeprived smokers or nonsmokers, two reported that nicotine improved some aspects of memory in patients with Alzheimer s disease,77 112 two found enhanced reaction time on the Sternberg memory test,78,109 four reported no effect of nicotine on tests of immediate and delayed recall,76,77 91,113 and two found that nicotine polacrilex impaired immediate and/or delayed recall accuracy.83,114 Foulds et al.79 reported that SC nicotine enhanced response time but decreased accuracy in a digit recall test in nonsmokers. 

Meadow, A. (1999). Randomized comparative trials of nicotine polacrilex, a transdermal patch, nasal spray, and inhaler. Archives of Internal Medicine, 159, 2033-2038. 

Nicotine polacrilex Nicorette Nicotine- polacrilex gum Lakeside Pharmaceuticals (Merrell Dow) 2 mg, 4 mg Up to 24 pieces OTC... 

Nicotine bioavailability also varies with the delivery system. The reported bioavailability from the nasal spray and transdermal patch is 53% and 82%, respectively (93,184). In nicotine polacrilex gum, nicotine is bound to an ion exchange resin and is released only by chewing. Nicotine bioavailability, therefore, is dependent on the vigor, rapidity, and duration of chewing. Of the 10 mg in each cartridge of a nicotine inhaler, only 4 mg is actually delivered from the device to the oral mucosa and is available for absorption. 

Nicotine polacrilex contains nicotine bound to an ion exchange resin in a chewing-gum base. The nicotine transdermal system is a multilayered unit containing nicotine as the active agent that provides systemic delivery of nicotine for 24 honrs following its application to intact skin. 

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