Smoking-cessation aid

Varenicline is the first approved nicotinic receptor partial agonist. In this respect, it differs from other smoking cessation aids, such as the nicotinic antagonist, bupropion and nicotine replacement therapies. In May 2006, it was approved for sale in the United States. Varenicline increased the odds of successful long-term smoking cessation approximately threefold compared with pharmacologically unassisted quit attempts. In trials reported so far, more participants quit successfully with varenicline than with bupropion (see Cahill et al., 2007). 

Bupropion belongs to the chemical class of aminoketones. It is an atypical antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist. Initially developed and marketed as an antidepressant, bupropion was subsequently found to be effective as a smoking cessation aid. If given to lactating women it can trigger convulsions in the newborn. 

Bupropion and also varenicline are mentioned in Chapter 21, Section I.c.4. Bupropion is a norepinephrine and dopamine reuptake inhibitor de-veoped as an antidepressant. It is now used on a large scale as a smoking cessation aid. Varenicline is the first nicotinic receptor partial agonist approved to treat smoking addiction. 

Various smoking cessation aids bupropion hydrochloride... 

Smoking cessation aids Nicotine polacrilex gum dosage varies consult product labeling Nicorette, various generic Nicotine replacement products in combination with behavioral support approximately double long-term cessation rates compared with placebo. Review directions for use carefully, since product strengths vary and self-titration and tapering may be necessary. 

Warner C, Shoaib M. How does bupropion work as a smoking cessation aid Addict Biol 2005 10 219-231. 

Wellbutrin) and as a smoking-cessation aid (Zyban). It has been proposed that Bupropion activity would come from its metabolite, (2S,35)-hydroxybupropi(Mi (Radafaxine). In order to evaluate the potential of phosphinolactone as lactol bioisostere, various ( )-oxazaphosphinanes 278 were synthesized and evaluated in vivo in a forced swimming test in mice [200]. 

Psychological Pregabalin treatment was associated with increased errors compared to placebo in a sustained attention task when given to patients as a smoking-cessation aid [147 ]. 

Bupropion (Zyban, Wellbutrin) (Smoking cessation aid antidepressant)... 

Methylation of the secondary amine of aT-norlobelanine (52) affords lobelanine (53), a precursor of the alkaloid lobeline (54), which is obtained upon selective reduction of a single carbonyl group and is commonly applied as a smoking cessation aid [9]. 

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