Nicotine tobacco and

General precautions for each medication that has been used for smoking cessation are listed in the sections describing each medication. All FDA-approved first-line medications for smoking cessation have a relatively good safety profile. Consensus opinions on the safety of the various medications for persons with cardiovascular disease, other medical conditions, and pregnancy are beyond the scope of this chapter but can be found elsewhere (Society for Research on Nicotine and Tobacco 2003). 

In general, for smokers with cardiac disease, the benefits of nicotine replacement therapy outweigh the potential risks. In a safety and efficacy study that included veterans with cardiac disease, smoking concurrently with the nicotine patch was not associated with an increase in adverse events (Joseph et al. 1996). Although bupropion SR is generally well tolerated by smokers, it has not been adequately studied in persons with cardiac disease, and definitive conclusions regarding its safety in this patient population cannot currently be made (Society for Research on Nicotine and Tobacco 2003). 

Society for Research on Nicotine and Tobacco Database and Educational Resource for the Treatment of Tobacco Dependence. Available at http //www.treatobacco. net. Accessed April 18, 2003. 

Saliva of 3 non-snufMipping women (controls) was free of nicotine and tobacco-specific N-nitrosamines. 

Mitsis, E.M., van Dyck, C.H., Krantzler, E. et al. Prolonged occupancy of nicotinic acetylcholine receptors by nicotine in human brain a preliminary study. Paper presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, Orlando, FL, 2006. 

In vivo Brain Imaging of Human Exposure to Nicotine and Tobacco... 

Balfour DJK (2004) The neurobiology of tobacco dependence a prechnical perspective on the role of the nucleus accumbens. Nic Tob Res 6 899-912 Balfour DJK (2006) Complementary roles for the accumbal shell and core in nicotine dependence. In Bock G, Goode J (eds) Understanding nicotine and tobacco addiction. Novartis Symp-soium 275. Wiley, Chichester, UK, pp 96-115... 

Drobes D, Klein LC (2004) Research on nicotine and tobacco a decade of progress. Nicotine Tob Res 6 695-741... 

Pomerleau OF, Hughes JR (2005) With a little help from its friends a brief history of the Society for Research on Nicotine and Tobacco. Nicotine Tob Res 6(3) 391-395 Miczek KA, Stolerman IP, Henningfield JE (eds) (2006) Special issue on nicotine. Psychopharmacology 184(3 ) 263-652... 

Part I Nicotine and Tobacco Consnmption Measnrement and Trends... 

Society for Research on Nicotine and Tobacco. Online. Available HTTP (accessed 2 April 2003). 

Levin E, Connors CK, Sparrow E, et al Nicotine effects in attention deficit hyperactivity disorder. Paper presented at 1st annual meeting. Society for Research on Nicotine and Tobacco, San Diego, March 24-25, 1995 Levine J, Rapaport A, Lev L, et al Inositol treatment raises CSF inositol levels. Brain Res 627 168-170, 1993... 

---