Discovery toxicology

Rodi CR et al. Revolution through genomics in investigative and discovery toxicology. Toxicol Pathol 1999 27 107-110. 

Although in the past biotransformation to produce protein-reactive products has not been considered important in discovery toxicology studies, this situation appears to be changing. The limiting factor has been availability of radiolabeled drug to conduct appropriate covalent binding studies, but strategies have been proposed to overcome this obstacle [25],... 

Fernandes T.G. Diogo M.M. Clark D.S. Dordick J.S. Cabral J. High-throughput cellular microarray platforms Applications in drug discovery, toxicology and stem cell research. Trends in Biotechnology, 2009, 27, 342-349. 

Kramer JA, Sagartz JE, Morris DL. The apphcation of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nature Reviews Drug Discovery 6 636-649 (2007). 

Discovery Toxicology Screening Predictive, In Vitro Cytotoxicity... 

Discovery Toxicology, Bristol Myers Squibb Co., Princeton, New Jersey, U.S.A. 

Robust and rugged LC-MS/MS methods are essential in support of drug discovery, toxicology studies, and clinical trials, for the data generated from these bioanalytical methods is used to evaluate the bioavailability, bioequivalence, toxicokinetic, and pharmacokinetic parameters of drug candidates. Thus, it is critical to invest significant thought and effort in the method development process [25-27], Fast sample... 

Figure 10-1 Alignment of safety profiling, discovery toxicology, and pathology with the pre-clinical drug discovery process8. Profiling assays are implemented according to requirement of the phase, compound availability, and capacity. The complexity is increasing as projects progress toward clinical candidate selection.

Fieldent MR, Kolaja KL. The role of early in vivo toxicity testing in drug discovery toxicology. Expert Opin Drug Saf. 2008 7(2) 107-110. 

Discovery Toxicology Bristol-Myers Squibb Princeton, NJ... 

Discovery toxicology/long-term toxicology Rodent ADME Nonrodent ADME... 

Car B D, Robertson R T (1999). Commentary Discovery toxicology-a nascent science. Toxicol. Pathol. 27 481-483. 

The drug development process is a time-consuming process. It would take over 10 years to bring a new chemical entity (NCE) to the market. The drug development process generally consists of three periods discovery/toxicology, clinical development, and commercialization. 

Drug Discovery Toxicology From Target Assessment to Translational Biomarkers, First Edition. Edited by Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, and Brandon D. Jeffy. 

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