Apoptosis, neutrophils cytokine regulation

Coxon A, Tang T, Mayadas N Cytokine-activated endothelial cells delay neutrophil apoptosis in vitro A role of granulocyte/macrophage colony-stimulating factor. J Exp Med 1999 190 923-933. Whyte M, Renshaw S, Lawson R, Bingle C Apoptosis and the regulation of neutrophil lifespan. Biochem Soc Trans 1999 27 802-807. 

Ottonello L, Frumento G, Arduino N, Bertolotto M, Dapino P, Mancini M, Dallegri F Differential regulation of spontaneous and immune complex-induced neutrophil apoptosis by proinflamma-tory cytokines. Role of oxidants, Bax and caspase-3. J Leukoc Biol 2002 72 125-132. 

Numerous signalling pathways have been implicated in regulation of neutrophil survival and cell death, as well as those stimulated when neutrophil apoptosis is delayed by cytokines. These pathways are not fully delineated and are reviewed by Akgul et al. [1]. 

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